ArticleJournal of medical physics
Evaluating the Predictive Value of the Dose-volume Parameters and Vascular Endothelial Growth Factor Expression on Rectal Toxicity in Prostate Cancer Patients.
Article in Journal of medical physics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The response to radiation varies widely among people. Despite recent advances to conform the dose distribution to the tumor volume, it is still impossible to perform radiotherapy based on the biological characteristics of each individual. In this case, identifying a biomarker can be a step toward personalizing treatment. This research was carried out to evaluate the predictive value of dose-volume parameters and vascular endothelial growth factor (VEGF) expression on rectal proctitis toxicity in prostate cancer patients. Materials and Methods: Eighteen patients with prostate cancer who underwent helical tomotherapy were included in the study. VEGF serum level before and after treatment was obtained. Furthermore, dosimetric parameters, including rectal volume, maximum dose, V50, V60, V65, V70, and V75 were extracted. Spearman's correlation coefficient of VEGF-related and dosimetric parameters with the grade ≥1 rectal proctitis was calculated. Results: In the rectal toxicity group, the mean value of VEGF increased significantly after treatment compared to before ( Conclusion: The results of the study confirm the correlation of VEGF expression with the pathobiology process of rectal radiation proctitis. However, the pathobiology process of radiation proctitis is complicated. More research is needed to prove the involvement of VEGF expression in the early detection of proctitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.