Evidence map›Paper›PMID 39926043›Full record

ReviewBiomedical reports2025

Therapeutic potential of garlic, aged garlic extract and garlic‑derived compounds on pancreatic cancer (Review).

Hiromichi Kawasaki, Gabriel Nussbaum

Abstract readReview
In one paragraph

Review in Biomedical reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. EvaluatingBiomedicines · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hiromichi KawasakiInstitute of Biomedical and Oral Research, Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Gabriel NussbaumInstitute of Biomedical and Oral Research, Hebrew University of Jerusalem, Jerusalem 9112102, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Garlic is a popular ingredient used in cuisines and traditional medicines worldwide. It contains numerous bioactive organosulfur-containing compounds, such as allicin, with reported potential for anticancer and antimicrobial therapy. The biological activity and potential use of garlic and its products have been extensively investigated. Aged garlic extract (AGE) is a product manufactured by aging garlic, and has been shown to have numerous health benefits. It has been previously revealed that several garlic-derived compounds, including AGE, have tumor-suppressive effects in various cancer models. Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, and carries a dismal prognosis. Recently, numerous tumors, including PDAC, were shown to harbor intracellular bacteria, some of which are oral pathogens. Tumor-associated bacteria have been linked to cancer progression. Garlic may inhibit tumor development, in part, by targeting these bacteria. Although it requires further investigation, pharmacological and antibacterial effects of garlic and its products could offer significant therapeutic benefits for the prevention and treatment of PDAC. In the present review, the therapeutic potential of garlic on PDAC is summarized and discussed.

Indexed as

aged garlic extractgarlicintratumor bacteriaoral pathogenorganosulfur compoundpancreatic cancer

Identifiers

PMID39926043
PMCPMC11803370

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.