ArticleHepatobiliary surgery and nutrition2025
Effects of exercise and nutrition in improving sarcopenia in liver cirrhosis patients: a systematic review and meta-analysis.
Article in Hepatobiliary surgery and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The impact of exercise on improving sarcopenia in patients with liver cirrhosis: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- The impact of very-low-calorie ketogenic diets on gut microbiota in individuals with obesity: a systematic review and meta-analysis.Gut microbes · 2025Pooled it
- Exercise and Nutrition for Sarcopenia: A Systematic Review and Meta-Analysis with Subgroup Analysis by Population Characteristics.Nutrients · 2025Pooled it
- The effect of a diet based on vegetable and dairy protein on biochemical and functional indicators of sarcopenia in patients with liver cirrhosis: a randomized controlled trial.Nutrition journal · 2025Trial
- Rethinking nutritional risk in cancer: muscle quality, myosteatosis, and prognosis.Hepatobiliary surgery and nutrition · 2026Article
- Burden of malnutrition and sarcopenia in patients with cirrhosis: pathophysiology, assessment, and management.Clinical and molecular hepatology · 2026Review
- Review
- Convergent bioprinting and microfluidics: toward next-generation biomimetic tumor models.Hepatobiliary surgery and nutrition · 2026Article
- Evidence-based strategies of exercise and nutrition in sarcopenia care in liver cirrhosis patients.Hepatobiliary surgery and nutrition · 2026Article
- Etiology, intervention duration, and standardization in sarcopenia management for liver cirrhosis: current challenges and future directions.Hepatobiliary surgery and nutrition · 2026Article
- Current management strategies for sarcopenia and frailty in cirrhosis: Missing link in transplant candidacy.World journal of hepatology · 2026Review
- Treadmill exercise improves motor deficits and partially normalizes electrophysiological properties of substantia nigra pars reticulata PV-lineage neurons in 6-OHDA-lesioned mice.Frontiers in physiology · 2026Article
- Serum Albumin Level Predicts Systemic Arterial Stiffening Mediated Partially by Change in Lean Body Mass: A Retrospective Cohort Study in General Japanese Population.Vascular health and risk management · 2026Article
- Sarcopenia's increasingly vital role in liver cancer.Hepatobiliary surgery and nutrition · 2025Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Sarcopenia is highly prevalent in patients with liver cirrhosis (LC), adversely affecting their quality of life and life expectancy. Exercise and nutrition represent common interventions to ameliorate sarcopenia in these patients, although there exists inconsistency in the reported effectiveness of these strategies. This study seeks to assess the impact of exercise and nutrition on sarcopenia in LC patients through a systematic review and meta-analysis. Methods: The research protocol was preregistered on PROSPERO, and adherence to PRISMA reporting guidelines was maintained throughout the systematic review process. Controlled vocabularies via Emtree, MeSH, and CINAHL Subject Heading were searched in five databases without any language limitation. The final analysis included only studies with a randomized controlled trial (RCT) design published by December 2021. The quality of these studies was assessed by the Cochrane ROB 2.0 version, and the meta-analysis was conducted using Review Manager 5.4 version. Results: A total of 262 studies were screened, and seven RCT studies involving 206 subjects were included in the meta-analysis. Exercise interventions encompassed muscle-strengthening, cardiopulmonary enhancement, and increased walking steps, while nutrition interventions included protein, branched-chain amino acids (BCAAs), carbohydrates, and vitamins. Most interventions had a duration of 8-12 weeks. Significant improvements in skeletal muscle index [mean difference (MD): 0.53, P=0.01, 95% confidence interval (CI): -0.10, 0.96, I Conclusions: Exercise and nutrition interventions demonstrate efficacy in improving sarcopenia in LC patients, with more pronounced effects observed with interventions lasting 12 months or longer. Skeletal muscle index and albumin levels in patients with LC can be positively influenced by exercise and nutrition strategies. Emphasizing a healthy diet and regular exercise is crucial for preventing sarcopenia in patients with LC.
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