Evidence map›Paper›PMID 39925813›Full record

ArticleFrontiers in immunology2025

Exhaustion of CD8

Florian Kälble, Jonas Leonhard, Martin Zeier, Oliver Zivanovic, Matthias Schaier, Andrea Steinborn

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Florian KälbleDepartment of Nephrology, University of Heidelberg, Heidelberg, Germany.
Jonas LeonhardDepartment of Nephrology, University of Heidelberg, Heidelberg, Germany.
Martin ZeierDepartment of Nephrology, University of Heidelberg, Heidelberg, Germany.
Oliver ZivanovicDepartment of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
Matthias SchaierDepartment of Nephrology, University of Heidelberg, Heidelberg, Germany.
Andrea SteinbornDepartment of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The role of regulatory CD8 Methods: In this study, we separately investigated the differentiation of CD8 Results: We found that RTE Treg differentiation via pathway 1 was age-independently increased in KTR, who developed graft rejection during the follow-up period, leading to abundant MN Treg and central memory Treg (CM Treg) production and favoring a strongly increased CD8 Conclusions: Our results show that exhaustive CD8

Indexed as

CD8-Positive T-LymphocytesCell DifferentiationGraft RejectionImmunologic MemoryKidney TransplantationT-Lymphocytes, RegulatoryAdultAgedFemaleHumansMaleMiddle AgedCD8pos regulatory T cellsCD8pos responder T cellsCD8pos T cell differentiationCD8pos T cell exhaustionimmunosuppressive therapykidney transplantationrejection

Identifiers

PMID39925813
PMCPMC11802571

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.