Evidence map›Paper›PMID 39925794›Full record

ArticleACG case reports journal2025

Cytarabine-Induced Hyperbilirubinemia in a Pregnant Patient With Acute Myeloid Leukemia.

Anjana Rajan, Abdelwahab Ahmed, Yalda Dehghan, Ji-Cheng Hsieh, Christopher Moore

Abstract readCase Reports
In one paragraph

Article in ACG case reports journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anjana RajanDepartment of Internal Medicine, Northwestern Memorial Hospital, Chicago, IL.ORCID https://orcid.org/0000-0001-5974-8898
Abdelwahab AhmedDepartment of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH.
Yalda DehghanDepartment of Gastroenterology and Hepatology, Northwestern Memorial Hospital, Chicago, IL.
Ji-Cheng HsiehDepartment of Internal Medicine, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.
Christopher MooreDepartment of Gastroenterology and Hepatology, Northwestern Memorial Hospital, Chicago, IL.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case study presents the first reported instance of cytarabine-induced hyperbilirubinemia in a pregnant patient undergoing treatment of acute myeloid leukemia. Despite experiencing direct hyperbilirubinemia during induction therapy, the patient exhibited no other signs of liver dysfunction. Lowering the cytarabine dose in subsequent cycles resulted in milder bilirubin elevations without compromising treatment efficacy. The patient gave birth to a healthy baby at term between cycles, underscoring the benign nature of this effect on both maternal and fetal health. This case contributes valuable insight into the management and outcomes of cytarabine-induced hyperbilirubinemia in a rare population: pregnant patients with acute myeloid leukemia.

Indexed as

acute myeloid leukemiacytarabinehyperbilirubinemiapregnancy

Identifiers

PMID39925794
PMCPMC11805562

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.