Evidence map›Paper›PMID 39925699›Full record

ArticleClinical medicine insights. Endocrinology and diabetes2025

Impact of Different Metabolic Indicators on Ventricular Repolarization Indices in Obese Children: A Case Control Study.

Asmaa A El Sehmawy, Rasha Abd El Samad Fawaz, Nadia Ahmed Agiba, Eman Aziz Elsherbiny, Nglaa Fathi Agaba, Doaa Sayed Mohammed, Haidy Mahmoud Nasr, Fatma Elzhraa Ae Diab, Amal M Ahmed, Shorouk Issa Mahfouz and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical medicine insights. Endocrinology and diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Asmaa A El SehmawyPediatrics Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.ORCID https://orcid.org/0000-0003-0609-1962
Rasha Abd El Samad FawazPediatrics Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Nadia Ahmed AgibaCardiology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Eman Aziz ElsherbinyCardiology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Nglaa Fathi AgabaPediatrics Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Doaa Sayed MohammedEndocrinology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Haidy Mahmoud NasrPediatrics Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Fatma Elzhraa Ae DiabClinical Pathology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Amal M AhmedPuplic Heath and Community medicine department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Shorouk Issa MahfouzEndocrinology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Heba T OkdaPediatrics Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Doaa Sadek AhmedPuplic Heath and Community medicine department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Obesity, insulin resistance, and dyslipidemia may impact ventricular repolarization in children. Objectives: The study aimed to identify the relationship between various metabolic indicators and ventricular repolarization indices among obese children compared to healthy ones. Methods: A case-control study included 90 children, divided into two groups: 45 obese children (cases) and 45 children with normal weight (controls). Electrocardiogram (ECG) readings were analyzed to calculate several parameters, including corrected QT (QTc), QTc dispersion (QTcd), JTc dispersion, and the TpTe interval, using 12-lead surface ECGs. Both groups were also assessed for lipid profiles, fasting plasma glucose (FPG), and serum insulin to calculate the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). Results: Obese children had significantly higher serum levels of triglycerides, cholesterol, LDL, fasting insulin, and HOMA-IR compared to controls. Also, they significantly had longer mean values of QTcd and JTcd with no significant difference in TpTe interval between both groups. A significant positive correlation was detected between QTc and JTc dispersion and the following variables: waist circumference, body mass index (BMI), blood pressure, fasting insulin, HOMA-IR index, and LDL. Additionally, no significant difference was revealed between obese children with and without metabolic syndrome regarding ventricular repolarization ECG parameters. Conclusion: Greater JTc dispersion (ms) and QTc dispersion (ms) were observed in obese children with a positive correlation to waist circumference, BMI, and insulin resistance.

Indexed as

ChildrenECGJT dispersionobesityQT dispersion

Identifiers

PMID39925699
PMCPMC11803729

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.