Evidence map›Paper›PMID 39925678›Full record

ReviewInternational journal of nanomedicine2025

Advances in Ultrasound-Targeted Microbubble Destruction (UTMD) for Breast Cancer Therapy.

Yunfeng Wu, Yuxi Liu, Han Wu, Mengying Tong, Linyao Du, Shuangsong Ren, Ying Che

Abstract readReview
In one paragraph

Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Orchestration of Tumor-Associated Macrophages in the Tumor Cell-Macrophage-CD8International journal of biological sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yunfeng WuDepartment of Ultrasound, The First Affiliated Hospital of Dalian Medical University, Liaoning, Dalian, People's Republic of China.
Yuxi LiuDepartment of Ultrasound, Shandong Second Medical University Affiliated Hospital, Shan Dong, Weifang, People's Republic of China.
Han WuDepartment of Ultrasound, The First Affiliated Hospital of Dalian Medical University, Liaoning, Dalian, People's Republic of China.
Mengying TongDepartment of Ultrasound, The First Affiliated Hospital of Dalian Medical University, Liaoning, Dalian, People's Republic of China.
Linyao DuDepartment of Ultrasound, The First Affiliated Hospital of Dalian Medical University, Liaoning, Dalian, People's Republic of China.
Shuangsong RenDepartment of Ultrasound, The First Affiliated Hospital of Dalian Medical University, Liaoning, Dalian, People's Republic of China.
Ying CheDepartment of Ultrasound, The First Affiliated Hospital of Dalian Medical University, Liaoning, Dalian, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is one of the most common types of cancer in women worldwide and is a leading cause of cancer deaths among women. As a result, various treatments have been developed to combat this disease. Breast cancer treatment varies based on its stage and type of pathology. Among the therapeutic options, ultrasound has been employed to assist in the treatment of breast cancer, including radiation therapy, chemotherapy, targeted immunotherapy, hormonal therapy, and, more recently, radiofrequency ablation for early-stage and inoperable patients. One notable advancement is ultrasound-targeted microbubble destruction (UTMD), which is gradually becoming a highly effective and non-invasive anti-tumor modality. This technique can enhance chemical, genetic, immune, and anti-vascular therapies through its physical and biological effects. Specifically, UTMD improves drug transfer efficiency and destroys tumor neovascularization while reducing toxic side effects on the body during tumor treatment. Given these developments, the application of ultrasound-assisted therapy to breast cancer has gained significant attention from research scholars. In this review, we will discuss the development of various therapeutic modalities for breast cancer and, importantly, highlight the application of ultrasound microbubble-targeted disruption techniques in breast cancer treatment.

Indexed as

Breast NeoplasmsMicrobubblesUltrasonic TherapyAnimalsAntineoplastic AgentsDrug Delivery SystemsFemaleHumansAntineoplastic Agentsbreast cancerchemotherapymicrobubbleradiofrequency ablationTMEultrasound-targeted microbubble destruction

Identifiers

PMID39925678
PMCPMC11804227

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.