ArticleCureus2025
The Association Between Pre-morbid Frailty and Discontinuation of Treatment Within 24 Hours in Critically Ill Older Adults Triaged to a Tertiary Care Emergency Department: A Retrospective Cohort Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Some critically ill older adults would rather receive palliative than intensive care if their functional capacity and quality of life are compromised. Therefore, careful goals-of-care conversation is vital in frail older adults who are critically ill if there is no advance care planning before arrival at the emergency department. We considered that pre-morbid Clinical Frailty Scale (CFS) scores could be a potent factor in prioritizing such conversations if higher numbers were associated with increased withdrawal of treatment in these patients. This study aimed to investigate the association between pre-morbid frailty and discontinuation of treatment within 24 hours in older adults in Kobe, Japan. Methodology This retrospective, observational study was conducted among patients aged 65 and over who were triaged as needing tertiary care to our emergency department with subsequent admission for further treatment. The primary outcome was withdrawal of treatment within 24 hours. We examined the association between CFS and withdrawal of treatment using a multivariable logistic regression model with CFS 1-4 as a reference. Results During the study period, 1,093 patients were triaged to our emergency department as needing tertiary care. After exclusion, 407 patients (median age = 80 years (interquartile range = 73-87)), were included in the study. Of these, 58 (14.2%) patients withdrew from intensive care within 24 hours. The adjusted odds ratios were 1.99 for CFS 5 (95% confidence interval (CI) = 0.74-5.32, p = 0.17), 2.48 for CFS 6 (95% CI = 0.93-6.57, p = 0.068), and 5.48 for CFS 7-9 (95% CI = 2.68-12.6, p < 0.01). Conclusions Higher CFS scores in critically ill older adults were associated with a higher likelihood of withdrawal within 24 hours. The goals-of-care conversation could be held proactively when CFS scores are high to reduce unwanted medical intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.