Evidence map›Paper›PMID 39925553›Full record

ArticleCureus2025

Acute Myelomonocytic Leukemia: A Rare Cause of Painless Jaundice.

Amey Joshi, Rohan Kumar, Ankit Kulkarni, Ryan K Mui, Adarsh Jha, Tadd K Hiatt

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amey JoshiInternal Medicine, Michigan State University, Lansing, USA.
Rohan KumarInternal Medicine, Michigan State University, Lansing, USA.
Ankit KulkarniInternal Medicine, Michigan State University, Lansing, USA.
Ryan K MuiGastroenterology, Michigan State University, Lansing, USA.
Adarsh JhaInternal Medicine, Michigan State University, Lansing, USA.
Tadd K HiattGastroenterology, University of Michigan, Lansing, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute myelomonocytic leukemia (AMML) is a rare and aggressive subtype of acute myeloid leukemia with varying clinical manifestations. Although hepatic involvement in AMML is commonly seen, cholestatic hepatitis as a primary manifestation of the disease is very rare. In the present case, our elderly patient presented with predominant signs of cholestasis, including jaundice, nausea, and vomiting. However, after a thorough diagnostic workup that ruled out obstructive, viral, or drug-induced etiologies, the presence of severe thrombocytopenia prompted further investigation. Flow cytometry was ultimately utilized to diagnose our patient with AMML. This case highlights that laboratory evidence of hematological abnormalities, including thrombocytopenia, could aid in diagnosing unexplained cholestasis outside the recommended workup.

Indexed as

acute myeloid leukemia (aml-m6)cholestasisjaundice cholestaticnew-onset painless jaundicethrombocytopenia

Identifiers

PMID39925553
PMCPMC11807341

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.