ReviewCureus2025
Safety and Efficacy of Vaccines During Pregnancy: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Review
- Contextualizing Racial and Ethnic Inequities in COVID-19 Vaccination Uptake During Pregnancy Through a Community-Led Evaluation.Birth defects research · 2026Article
- Maternal Vaccine Acceptance and Attitudes Before and After the COVID-19 Pandemic: A Narrative Literature Review.Vaccines · 2026Review
- Current Understanding of Meningitis Pathogens, Immunity Gap, and Future Prevention Strategies in Sri Lanka: A Narrative Review.International journal of microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal immunization is a safe and effective strategy for protecting mothers and infants from vaccine-preventable diseases. This systematic review evaluated the safety and efficacy of various vaccines administered during pregnancy, focusing on maternal and infant outcomes. A comprehensive literature search was conducted in PubMed, Scopus, and Web of Science to identify relevant studies. The search used terms and combinations such as ("maternal vaccination" OR "vaccination during pregnancy") AND ("safety" OR "efficacy" OR "immunogenicity") AND ("influenza" OR "DTaP" OR "respiratory syncytial virus" OR "group B streptococcus" OR "COVID-19"). Boolean operators "AND" and "OR" enhanced precision and filtered the limited results to studies published from 2018 to 2024. Eight studies were included in the review after applying inclusion and exclusion criteria. Influenza, diphtheria-tetanus-pertussis, respiratory syncytial virus, group B streptococcus, and COVID-19 vaccines are safe and effective when administered during pregnancy. These vaccines elicit robust immune responses in pregnant women, with efficient transplacental antibody transfer providing passive immunity to newborns. Adverse effects were mostly mild to moderate and similar to those observed in nonpregnant individuals. No significant increase in adverse pregnancy or neonatal outcomes was associated with maternal vaccination. Most of the included randomized controlled trials (had a low risk of bias, thus supporting the reliability of the findings. However, vaccine hesitancy remains a challenge, highlighting the need for transparent communication between healthcare providers and pregnant women. Future research should focus on long-term infant health outcomes, vaccine safety, immunogenicity in diverse populations, and strategies to optimize maternal immunization timing and enhance neonatal antibody persistence. This review supports the implementation of routine maternal vaccination programs and emphasizes the importance of addressing knowledge gaps and ensuring equitable access to immunization during pregnancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.