Evidence map›Paper›PMID 39925439›Full record

ArticleGlobal medical genetics2025

The genetic susceptibility of SOD2 gene polymorphism in sudden sensorineural hearing loss (SSNHL).

Jiahong Deng, Guifang Ma, Xianbao Cao, Yulian Chen, Lv Hu, Jinqian Zhang

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In one paragraph

Article in Global medical genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jiahong DengDepartment of Otorhinolaryngology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157, Rd. Jinbi, Kunming 650032, China.
Guifang MaDepartment of Otorhinolaryngology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157, Rd. Jinbi, Kunming 650032, China.
Xianbao CaoDepartment of Otorhinolaryngology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157, Rd. Jinbi, Kunming 650032, China.
Yulian ChenDepartment of Otorhinolaryngology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157, Rd. Jinbi, Kunming 650032, China.
Lv HuCollege of Life Science and Technology, Kunming University of Science and Technology, No. 68, Rd. Wenchang, Kunming 650093, China.
Jinqian ZhangDepartment of Otorhinolaryngology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157, Rd. Jinbi, Kunming 650032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The genic etiology of sudden sensorineural hearing loss (SSNHL) is associated with gene polymorphism which is related to oxygen metabolism of cochlear hair cells. Objective: To investigate the genetic susceptibility of SOD2 gene polymorphism in sudden sensorineural hearing loss (SSNHL). Method: The genotype of three tag SNPs (rs5746136, rs2842960, rs4880) variants were detected among 148 patients with SSNHL in Yunnan Province, China, and 171 matched participants without hearing loss in control group were used to screen for any risk-associated SNPs. Result: The A/G genotype at rs5746136 locus ( Conclusion: SOD2 gene with the rs5746136 A/G genotype is associated with an increased risk of sudden sensorineural hearing loss (SSNHL), whereas the other two tag SNPs, rs2842960 and rs4880, show no significant correlation with SSNHL. Specifically, the tag SNP rs5746136 A/G appears to be a susceptibility gene for SSNHL.

Indexed as

Single nucleotide polymorphismSOD2Sudden sensorineural hearing loss (SSNHL)

Identifiers

PMID39925439
PMCPMC11800302

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.