ArticleJournal of veterinary internal medicine
Analysis of survival among biopsy-determined categories of kidney disease in dogs.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Survival of dogs with glomerular disease in Europe: insights from the European Veterinary Renal Pathology Service.Journal of veterinary internal medicine · 2026Article
- Chronic renal disease detection developments with future potential to improve veterinary clinical practice.Frontiers in veterinary science · 2026Review
- The Erythrocyte Sedimentation Rate as a Novel Prognostic Marker in Canine Inflammatory Diseases.Animals : an open access journal from MDPI · 2025Article
- Chlorambucil Monotherapy in Dogs with Protein-Losing Nephropathy of Probable Immune Origin: A Preliminary Study.Veterinary sciences · 2025Article
- Analysis of survival among biopsy-determined categories of kidney disease in dogs.Journal of veterinary internal medicineArticle
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Authors and funding
7 authors.
Funding
Abstract
backgroundThere are many causes of kidney disease in dogs. The association of the diagnostic category with survival is unknown.
objectiveDetermine survival outcomes for biopsy-determined diagnostic categories of kidney disease in dogs. ANIMALS: Six hundred forty-nine dogs were biopsied for evaluation of kidney disease.
methodsRetrospective study. Survival information was obtained for dogs whose kidney biopsy was submitted to the International Veterinary Renal Pathology Service between 2008 and 2018. Signalment, serum creatinine (sCr), urine protein : creatinine ratio (UPCR), and serum albumin (sAlb) were reported at the time of biopsy. Cox proportional hazards analysis was performed for the 14 categories with >10 cases having follow-up to determine hazard ratios (HR), using focal segmental glomerulosclerosis (FSGS) as baseline.
resultsThe median survival time (MST) for all dogs with follow-up (n = 649) was 608 days (interquartile range [IQR]: 109-1475 days). The most follow-up was obtained for FSGS (n = 138, MST 536 days). Dogs with renal amyloidosis (n = 80) had the shortest survival (MST 76 days, IQR 8-299 days) and, in the multivariate analysis including age, sCr, sAlb, and UPCR, an increased risk of death (HR 1.79 [95% CI: 1.22-2.65], P < .01). Dogs with podocytopathy, membranous glomerulonephritis (MGN), mixed MGN, membranoproliferative GN (MPGN), and mixed MPGN had decreased risk of death. Regardless of category, increasing age, sCr, and UPCR and decreased sAlb were associated with a greater risk of death.
conclusionsThe diagnostic category is associated with survival in dogs with kidney disease. Survival of individual dogs within each category was highly variable.
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