ArticleBrain and behavior2025
Are Adults With Bipolar Disorder at Increased Cardiovascular Risk due to Their Physical, Biochemical, and Physiological Profiles? The FINEXT-BD Study.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- The Mental Health-Acute Coronary Syndrome Continuum: Bidirectional Pathophysiological Links and Clinical Implications.Medical sciences (Basel, Switzerland) · 2026Review
- Cardiovascular risk assessment with SCORE2 and targeted health dialogues in primary care patients with mental illness.PloS one · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionBipolar disorder (BD) is associated with considerable morbidity and premature mortality, mainly due to somatic causes. This study aims to determine some physical, exercise capacity-related physiological variables and biochemical markers of health status in adults (45.4 ± 13.1 years) with BD (n = 65) compared to a healthy control (HC) population (n = 29) sample and to estimate cardiovascular risk (CVR) through different methods in the BD group.
methodsMultiple assessments included body composition, cardiorespiratory fitness (CRF), and biochemical parameters. CVR was calculated using the Framingham Heart Study, SCORE2, and relative risk methods.
resultsThe BD population, compared to the HC, showed unfavorable body composition (waist-to-hip ratio, 0.9 ± 0.1 vs. 0.8 ± 0.1; fat body mass, 33.3 ± 10.2 vs. 24.3 ± 8.9%, p ≤ 0.001), CRF (peak oxygen uptake, 25.2 ± 8.2 vs. 33.4 ± 8.7 mL kg
conclusionsThis study highlights the importance of specific physical, biochemical, and physiological screening and CVR and vascular age assessment for people with BD. The practical application of these findings would prevent cardiovascular disease in BD and promote a healthier lifestyle as an adjuvant strategy to pharmacological intervention.
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