Trial reportActa oncologica (Stockholm, Sweden)2025
SleepNow - A combined cognitive behavioral therapy for insomnia and physical exercise intervention in men with metastatic prostate cancer: results from a feasibility randomized controlled trial.
Trial report in Acta oncologica (Stockholm, Sweden), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of different intervention modalities combined with exercise in patients with insomnia: a systematic review and network meta-analysis.Frontiers in public health · 2026Pooled it
- Efficacy of walking or exercise for improving perceived cognitive function in adults during and after cancer therapy: a systematic review and network analysis.Journal of cancer survivorship : research and practice · 2026Review
- Individualized Physiotherapy Improves Quality of Life and Symptom Burden in Advanced Cancer: A Quasi-Experimental Study.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Article
- Mindfulness-based interventions and cognitive behavioral therapy for depression, anxiety, and stress in adults with chronic conditions: a stratified subgroup meta-analysis.Npj mental health research · 2026Article
- The impact of different exercise modes on prostate cancer: a Bayesian network meta-analysis.Scientific reports · 2026Article
- Pharmacologic management of postoperative sleep disturbance in breast cancer.Frontiers in pharmacology · 2026Review
- The assessment of sleep disturbances in cancer patients when measured with single items.Frontiers in psychology · 2026Article
- Cancer survivorship and functional health: what we need to address in an aging cancer population.Acta oncologica (Stockholm, Sweden) · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
focused on patients living with metastatic cancer. We examined the feasibility of the SleepNow intervention combining cognitive behavioral therapy for insomnia (CBT-I) with physical exercise in men with metastatic prostate cancer (mPCa). PATIENTS/MATERIAL AND
methodsWe conducted a feasibility randomized trial in patients under treatment for castration resistant mPCa with insomnia (Insomnia Severity Index [ISI] score ≥ 8). Patients were randomized 1:1 to either SleepNow or usual care. SleepNow is a manualized 12-week program consisting of bi-weekly sessions of physical exercise and four nurse-led sessions of CBT-I. Patients in usual care received no insomnia treatment. We assessed feasibility and measured objective and patient-reported outcomes at baseline and 3-months follow-up. Changes in both groups were compared using the Wilcoxon test.
resultsWe randomized 12 patients (5 intervention and 7 control; age range = 59-81 years, mean Gleason score = 7.75, mean time since diagnosis ≈ 7 years). Intervention patients reported high satisfaction, all attended at least three CBT-I sessions (75%) and four completed at least 20 of the 24 training sessions. The intervention group showed improvements in insomnia, sleep quality, fatigue, anxiety, depression and health-related quality-of-life but between-group differences were not statistically significant.
interpretationThe SleepNow intervention is the first to combine nurse-delivered CBT-I and physical exercise and was acceptable and potentially efficacious. Our results are important for targeting sleep interventions to the growing population of patients living long term with metastatic cancer.
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