Evidence map›Paper›PMID 39924956›Full record

ArticleACS chemical biology2025

Insights into Free Drug Release from Efficacious

Nilanjana Chakraborty, Jelena Momirov, Aleksandar Radakovic, Shreyosree Chatterjee, Aaron M Kirchhoff, Anna-Lena Kolb, Thomas J West, Brittany B Sanchez, Salvador Martinez-Bartolome, Anthony Saviola and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Supernatural Products.The Chemist · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nilanjana ChakrabortyDepartment of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
Jelena MomirovDepartment of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
Aleksandar RadakovicDepartment of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
Shreyosree ChatterjeeDepartment of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
Aaron M KirchhoffDepartment of Molecular Medicine, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
Anna-Lena KolbDepartment of Molecular Medicine, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
Thomas J WestDepartment of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
Brittany B SanchezDepartment of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
Salvador Martinez-BartolomeDepartment of Molecular Medicine, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
Anthony SaviolaDepartment of Molecular Medicine, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0001-6890-512X
Daniel McClatchyDepartment of Molecular Medicine, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0002-0288-5645
John R YatesDepartment of Molecular Medicine, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0001-5267-1672
Jason S ChenDepartment of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
Luke L LairsonDepartment of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0001-6701-996X
Brunie H FeldingDepartment of Molecular Medicine, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
Dale L BogerDepartment of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0002-3966-3317

Funding

Scripps Translational Science InstituteUL1TR002550 · NCATS · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2018 to 2022
$28.9M
ANTITUMORE ANTIBIOTICS: STREPTONIGRIN AND LAVENDAMYCINR01CA042056 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI BOGER, DALE L · 1985 to 2024
$10.6M
Proteogenetics of Autism Spectrum DisordersR01MH100175 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI MUOTRI, ALYSSON R., YATES III, JOHN R · 2013 to 2025
$7.4M
Modulating Signaling Endocannabinoids and Fatty Acid AmidesR37DA015648 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI DALE L BOGER · 2018 to 2026
$3.8M
Modulating Signaling Endocannabinoids and Fatty Acid AmidesR01DA015648 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI BOGER, DALE L · 2002 to 2017
$3.7M
A Unique Class of Reductively Activated Oncology DrugsR01CA208669 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI BOGER, DALE L, FELDING, BRUNIE H. · 2017 to 2021
$3.6M
A RIPK2-Targeting Apoptosis-Inducing Small Molecule for the Treatment of GlioblastomaR01NS112482 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI LAIRSON, LUKE LEE · 2019 to 2023
$2.6M
NCATS NIH HHS UL1 TR002550NCI NIH HHS R01 CA042056NCI NIH HHS R01 CA208669NIDA NIH HHS R01 DA015648NIDA NIH HHS R37 DA015648NIMH NIH HHS R01 MH100175NINDS NIH HHS R01 NS112482
6 · The paper itself

Abstract

Acyclic and cyclic

Indexed as

DuocarmycinsProdrugsAminophenolsAnimalsAntineoplastic AgentsCell Line, TumorDrug LiberationHumansIndolesAminophenolsAntineoplastic Agentsduocarmycin ADuocarmycinsIndolesProdrugs

Identifiers

PMID39924956
PMCPMC11908632

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.