Evidence map›Paper›PMID 39924933›Full record

ArticleBrain and behavior2025

Nonmotor Symptoms Differ Between Essential Tremor and Tremor-Dominant Parkinson's Disease.

Mingqiang Li, Runcheng He, Xun Zhou, Yuzheng Wang, Qiying Sun, Chunyu Wang, Sheng Zeng, Lifang Lei, Heng Wu, Shanqing Yi and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Clinical Features of Essential Tremor and its Impact on Quality of Life in Japan.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mingqiang LiDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Runcheng HeDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xun ZhouDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID https://orcid.org/0000-0002-7325-5720
Yuzheng WangDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Qiying SunDepartment of Geriatric Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID https://orcid.org/0000-0002-2031-8345
Chunyu WangDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID https://orcid.org/0000-0003-0813-2801
Sheng ZengDepartment of Geriatric Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lifang LeiDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Heng WuDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Shanqing YiDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Jun WenDepartment of Neurology, The First People's Hospital of Changde, Changde, Hunan, China.
Qian XuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID https://orcid.org/0000-0002-5223-9967
Jifeng GuoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Beisha TangDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
China Essential Tremor Alliance

Funding

National Natural Science Foundation of China U20A20355
6 · The paper itself

Abstract

backgroundDistinguishing between essential tremor (ET) and tremor-dominant Parkinson's disease (PD-TD) can be challenging due to overlapping motor symptoms. This study aims to investigate the differences in nonmotor symptoms (NMS) between ET and PD-TD patients to provide additional evidence for differentiating these two conditions.

methodsThis retrospective study included 1656 participants, comprising 558 PD-TD patients, 584 ET patients, and 514 controls. ET patients were assessed using the Tremor Research Group Essential Tremor Rating Assessment Scale (TETRAS), while PD-TD patients were evaluated based on the Unified Parkinson's Disease Rating Scale (UPDRS). All participants were assessed for NMS using the Nonmotor Symptoms Scale (NMSS).

resultsThe composite NMSS score for the PD-TD group was significantly higher than that for the ET group and the control group (23.44 ± 20.20 vs. 12.60 ± 14.89 vs. 9.37 ± 12.44, p < 0.001). Compared to ET patients, PD-TD patients had an increased risk of all NMS, especially in hyposmia (OR = 7.70, 95% CI: 5.11-11.62). The NMSS score, urinary symptoms, and hyposmia may play a role in differentiating ET from PD-TD. The area under the curve (AUC) is 0.766 (95% CI: 0.739-0.793), with a sensitivity of 80.8% and specificity of 58.6%. When family history is included in the analysis, the AUC increases to 0.819 (95% CI: 0.795-0.843), with sensitivity improving to 82.4% and specificity to 68.2%.

conclusionsThe study reveals significant differences in NMS between ET and PD-TD. Compared to patients with ET, those with PD-TD exhibit more frequent and severe NMS. NMS and family history are helpful in differentiating between ET and PD-TD.

Indexed as

Essential TremorParkinson DiseaseTremorAgedDiagnosis, DifferentialFemaleHumansMaleMiddle AgedRetrospective StudiesSeverity of Illness Indexessential tremorhyposmianonmotor symptomtremor‐dominant Parkinson's disease

Identifiers

PMID39924933
PMCPMC11808177

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.