Evidence map›Paper›PMID 39924635›Full record

ArticleThe protein journal2025

Low-dose Bee Venom as a Potential Therapeutic Agent Against Human Chronic Myeloid Leukaemia Cells.

Hamza Halici, Harun Un, Saffet Celik, Zeynep Karakoy, Zafer Bayraktutan, Can Ozlu, Elif Cadirci, Zekai Halici, Alptug Atila, Filiz Mercantepe

Abstract read
PubMed Publisher
In one paragraph

Article in The protein journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Therapeutic Bioactivity Exerted by theMolecules (Basel, Switzerland) · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hamza HaliciDepartment of Hınıs Vocational Training School, Ataturk University, Erzurum, Turkey.ORCID http://orcid.org/0000-0002-2028-6603
Harun UnDepartment of Biochemistry, Agri Ibrahim Cecen University, Faculty of Pharmacy, Ağrı, Turkey.ORCID http://orcid.org/0000-0003-1772-282X
Saffet CelikTrakya University, Technological Research, Development and Design Application and Research Center, Edirne, Turkey.ORCID http://orcid.org/0000-0002-4225-2471
Zeynep KarakoyDepartment of Pharmacology, Erzincan Binali Yıldırım University, Faculty of Pharmacy, Erzincan, Turkey.ORCID http://orcid.org/0000-0002-4281-0103
Zafer BayraktutanDepartment of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey.ORCID http://orcid.org/0000-0002-4324-5943
Can OzluDepartment of Internal Medicine, Division of Hematology, University of Health Sciences, Kütahya, Turkey.ORCID http://orcid.org/0000-0002-9573-1177
Elif CadirciDepartment of Pharmacology, Ataturk University, Faculty of Medicine, Erzurum, Turkey. ecadirci@atauni.edu.tr.ORCID http://orcid.org/0000-0003-0836-7205
Zekai HaliciDepartment of Pharmacology, Ataturk University, Faculty of Medicine, Erzurum, Turkey.ORCID http://orcid.org/0000-0001-6854-6059
Alptug AtilaDepartment of Analytical Chemistry, Ataturk University Faculty of Pharmacy, Erzurum, Turkey.ORCID http://orcid.org/0000-0001-7027-809X
Filiz MercantepeDepartment of Internal Medicine, Division of Endocrinology and Metabolic Diseases, Recep Tayyip Erdoğan University Training and Research Hospital, Rize, Turkey.ORCID http://orcid.org/0000-0002-4325-1534

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bee venom is secreted by a gland in the abdominal cavity of bees. The venom, especially that of honeybees, contains certain enzymes and peptides that, when administered in high doses, are effective against various diseases. Peptides such as melittin and phospholipase A

Indexed as

Antineoplastic AgentsBee VenomsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveAnimalsBeesCell ProliferationCell SurvivalHumansK562 CellsMelittenProteomicsAntineoplastic AgentsBee VenomsMelittenBee venomChronic myeloid leukaemiaCytotoxicityK-562 cellMTT

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.