Evidence map›Paper›PMID 39924613›Full record

ArticlePsychopharmacology2025

Influence of real-world cue exposure and mood states on drinking: testing neurobiological models of alcohol use disorder.

Lindsay R Meredith, Wave-Ananda Baskerville, Carrie Lee, Erica N Grodin, Kate M Wassum, Lara A Ray

Erratum issuedAbstract read
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In one paragraph

Article in Psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Kava (Nutrients · 2026
    Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Lindsay R MeredithDepartment of Psychology, University of California, Los Angeles, CA, USA.
Wave-Ananda BaskervilleDepartment of Psychology, University of California, Los Angeles, CA, USA.
Carrie LeeDepartment of Psychology, University of California, Los Angeles, CA, USA.
Erica N GrodinDepartment of Psychology, University of California, Los Angeles, CA, USA.
Kate M WassumDepartment of Psychology, University of California, Los Angeles, CA, USA.
Lara A RayDepartment of Psychology, University of California, Los Angeles, CA, USA. lararay@psych.ucla.edu.

Funding

The Role of Striosome Neurons in Mediating Opiod RewardP50DA005010 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WALWYN, WENDY M · 1987 to 2021
$30.7M
Clinical Neuroscience of Alcoholism: Integrating Neuroscience and Clinical TrialsK24AA025704 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY · 2018 to 2026
$1.3M
Neuroimmune Treatment for AUD: Testing Moderators of Clinical Response and Mechanisms of ActionF31AA029295 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MEREDITH BROUSSARD, LINDSAY · 2022 to 2023
$59k
NIAAA NIH HHS F31 AA029295NIAAA NIH HHS F31AA029295NIAAA NIH HHS K24 AA025704NIAAA NIH HHS K24AA025704NIDA NIH HHS P50 DA005010NIDA NIH HHS P50 DA005010-33
6 · The paper itself

Abstract

rationaleTwo prominent neurobiological models of addiction, the allostatic and incentive-sensitization models, have guided clinical research on alcohol use disorder (AUD). While these models are often viewed in isolation, it is plausible these theories are complimentary.

objectivesUse naturalistic, daily diary reports to determine whether positive and negative mood states influence alcohol cue sensitivity in a clinical sample with AUD.

methodsThis is an exploratory analysis of daily diary data collected from a non-treatment seeking sample with current AUD over two weeks. Eligible adult participants (N = 50) were enrolled in a medication trial for AUD. Each morning, participants retrospectively reported on pre-drinking mood states, alcohol cue exposure, and craving levels, and subsequent alcohol intake occurring the previous day. Multilevel models tested the singular and interactive relationships between cue exposure and mood states with craving and drinking. Within-person and between-person outcomes were assessed. Exploratory analyses examined whether individuals with withdrawal-related dysphoria were more vulnerable to mood states and cue-reactivity.

resultsGreater cue exposure was associated with higher daily drinking levels (p = .001), but not daily alcohol craving. Higher negative mood (p < .0001) and lower positive mood (p = .012) were associated with higher daily alcohol craving, but not same-day drinking. As negative mood levels increased (p < .01) and positive mood levels decreased (p = .010), the relationship between cue exposure and same-day drinking became stronger. These findings were most pronounced among those with withdrawal-related dysphoria.

conclusionsFindings provided concomitant support for the allostatic model and incentive-sensitization model as determinants of alcohol craving and drinking among individuals with AUD.

Indexed as

AffectAlcohol DrinkingAlcoholismCuesAdultCravingFemaleHumansMaleMiddle AgedRetrospective StudiesAlcohol use disorderAllostaticCue exposureDaily diaryIncentive-sensitizationNaturalistic reportingNegative emotionality

Identifiers

PMID39924613
PMCPMC12296835

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.