Evidence map›Paper›PMID 39924608›Full record

ArticleClinical rheumatology2025

Early axial spondyloarthritis versus established disease: a single-center analysis based on the new ASAS definition of early disease.

Sara Alonso, Paula Alvarez, Norma Calleja, Rubén Queiro

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Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Sara AlonsoRheumatology Division, Hospital Universitario Central de Asturias (HUCA), Avenida de Roma S/N, 33011, Oviedo, Spain.
Paula AlvarezRheumatology Division, Hospital Universitario Central de Asturias (HUCA), Avenida de Roma S/N, 33011, Oviedo, Spain.
Norma CallejaRheumatology Division, Hospital Universitario Central de Asturias (HUCA), Avenida de Roma S/N, 33011, Oviedo, Spain.
Rubén QueiroRheumatology Division, Hospital Universitario Central de Asturias (HUCA), Avenida de Roma S/N, 33011, Oviedo, Spain. queiromanuel@uniovi.es.ORCID http://orcid.org/0000-0002-8418-7145

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe applicability of the new Assessment of Spondyloarthritis International Society (ASAS) consensus definition of early axial spondyloarthritis (axSpA) has barely been tested in clinical settings. We aimed to check the applicability of this new definition in a real clinical context.

methodsSingle-center cross-sectional study involving 330 consecutive patients fulfilling axSpA criteria. Similarities and differences between patients with early (according to the new ad hoc definition) and established disease were analyzed. Logistic regression models adjusted for sex and exposure to biologic therapies were constructed to analyze the different disease outcomes between both subpopulations.

resultsOf 299 patients for whom information on defining characteristics of early axSpA could be reliably collated, 45 (15%) met the ASAS definition of early axSpA, median disease duration of 1.0 year [IQR, 1.0-2.0]. Compared to established disease, these patients were younger (p = 0.001), with a similar male-to-female ratio, and a higher exposure to NSAIDs (p = 0.015) but lower to biologics (p = 0.005). Uveitis prevalence was similar between both groups (early, 15.6% and established, 16.1%). Regardless of sex and biologic therapy, inflammatory burden, disease activity and the impact on quality of life were similar in both groups. As expected, structural damage was higher among established cases. Also, regardless of disease duration and exposure to biologic therapies, men had better disease outcomes than women.

conclusionPatients with early axSpA present similarities and differences with respect to established cases. The new ASAS definition of early disease may be applicable in real-world clinical settings. KEY POINTS: • Patients with early axial spondyloarthritis show similarities and differences with respect to established cases. • The overall burden of disease is similar in both subgroups of patients with axial SpA. • In both study groups, men showed better disease outcomes than women. • The new ASAS definition of early axial spondyloarthritis is applicable in real-life clinical settings.

Indexed as

Axial SpondyloarthritisSpondylarthritisAdultBiological ProductsCross-Sectional StudiesFemaleHumansMaleMiddle AgedSeverity of Illness IndexUveitisBiological ProductsASASAxial spondyloarthritisUveitis

Identifiers

PMID39924608

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.