ArticlePediatric transplantation2025
Evaluating Activated Regulatory T Cells as a Biomarker of Chronic Allograft Inflammation in Pediatric Kidney Transplant Recipients.
Article in Pediatric transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Growth and development following paediatric kidney transplantation: Mechanisms, influencing factors, and clinical management.World journal of transplantation · 2026Review
- Effectiveness of treating NELL1-positive idiopathic membranous nephropathy on clinical outcomes, serum cytokine levels (IL-6, IL-10, IL-2, IL-17), nutritional status, and immune responses.Journal of medical biochemistry · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundThere is a need for noninvasive immunological biomarkers that can identify stable kidney allograft immune quiescence to inform individualized immunosuppression.
methodsWe conducted a cross-sectional, pilot cohort study evaluating the relative abundance of regulatory T cells (Tregs) to effector T-cell (Teff) populations as a surrogate marker of long-term graft tolerance. We obtained fresh peripheral blood mononuclear cell samples from stable pediatric kidney transplant recipients, most with recent surveillance biopsies to identify the presence or absence of chronic inflammation. Tregs were sub-phenotyped as naïve, memory, and activated Tregs (aTreg). Treg/Teff ratios were modeled for association with chronic inflammation and in the context of potential clinical features.
resultsTwenty-seven patient samples were included on standard immunosuppression (tacrolimus, mycophenolate, and prednisone) with a mean age of 9.2 ± 5.0 years, at 30.2 ± 21.7 months posttransplant. The ratio of aTreg (FOXP3
conclusionsThe proportion of peripheral blood aTregs/Teff cells in this pilot cohort of stable pediatric kidney transplant recipients was associated with immune quiescence. These data support further investigation into aTreg/Teff monitoring to inform precision immunosuppressive treatment.
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