ArticleJournal of gastroenterology and hepatology2025
The West Catching Up With the East: High-Magnification NBI Is Accurate for the Diagnosis of Gastric Neoplasia in a Western Population.
Article in Journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- The West Catching Up With the East: High-Magnification NBI Is Accurate for the Diagnosis of Gastric Neoplasia in a Western Population.Journal of gastroenterology and hepatology · 2025Article
- Lymph node metastases in early gastric cancer: Japanese Gastric Cancer Treatment Guidelines can be used for endoscopic resection in the West.Endoscopy international open · 2025Article
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4 authors.
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Abstract
BACKGROUND AND
aimAccurate endoscopic prediction of histology is key to recognition of early gastric neoplasia and selection of appropriate resection techniques. Narrow-band imaging with magnification (M-NBI) has proven to be highly accurate for gastric lesions in eastern countries; however, we sought to examine whether it can be effectively utilized in the west where evidence is scarce.
methodsThis is an analysis of a prospective database of gastric lesions at a single Australian center from 2009 to 2023. All lesions were assessed endoscopically using M-NBI and a determination made whether the lesion was neoplastic or non-neoplastic, as well as prediction of histological subtype. This was then correlated with final histology.
resultsA total of 232 lesions in 183 patients were included: 135 non-neoplastic and 97 neoplastic lesions. Thirty-five were adenomas, 29 early gastric cancers, and 6 advanced adenocarcinomas. For differentiating neoplastic versus non-neoplastic lesions, M-NBI had a sensitivity of 97.9% (CI 92.6%-99.7%) and specificity of 97.1% (CI 92.7%-99.2%). M-NBI was also highly accurate (97.0%, CI 93.9%-98.8%) for identifying lesions suitable for endoscopic resection. The observed agreement between the M-NBI predicted histology and the final pathology was 91.8% with a derived kappa statistic of 0.87, indicating excellent agreement. Comparatively, prior biopsies had an observed agreement of 40.4% with final histology, with a derived kappa statistic of 0.27.
conclusionsM-NBI can be used with a high degree of accuracy in a western population. M-NBI can effectively differentiate neoplastic from non-neoplastic gastric lesions and delineate histological subtypes with superior accuracy to previous biopsies.
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