Evidence map›Paper›PMID 39924240›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Caused by Influenza A Infection.

Satomi Okano, Akio Kimura, Takashi Ogasawara, Koji Tagawa, Miho Oshima, Mitsuo Narita, Toshiaki Oka, Tomoaki Murakami, Makoto Kaneda

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Satomi OkanoDepartment of Pediatrics, Sapporo Tokushukai Hospital, Japan.
Akio KimuraDepartment of Neurology and Genetics, Gifu University Graduate School of Medicine, Japan.
Takashi OgasawaraDepartment of Pediatrics, Sapporo Tokushukai Hospital, Japan.
Koji TagawaDepartment of Pediatrics, Sapporo Tokushukai Hospital, Japan.
Miho OshimaDepartment of Pediatrics, Sapporo Tokushukai Hospital, Japan.
Mitsuo NaritaDepartment of Pediatrics, Sapporo Tokushukai Hospital, Japan.
Toshiaki OkaDepartment of Pediatrics, Sapporo Tokushukai Hospital, Japan.
Tomoaki MurakamiDepartment of Pediatrics, Sapporo Tokushukai Hospital, Japan.
Makoto KanedaDepartment of Pediatrics, Sapporo Tokushukai Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a new spectrum of autoimmune inflammatory nervous system disorders associated with infection, neoplasm, or drug use. We present the first pediatric case of GFAP astrocytopathy caused by an influenza A infection. The patient manifested meningoencephalitis, central respiratory failure, quadriplegia, elimination disorders, and syndrome of inappropriate antidiuretic hormone secretion. Methylprednisolone pulse therapy led to a good prognosis. In cases of progressive atypical complications of influenza infection, immunotherapy-reactive GFAP astrocytopathy should be considered as a differential diagnosis for prompt treatment.

Indexed as

AstrocytesGlial Fibrillary Acidic ProteinInfluenza A virusInfluenza, HumanAutoantibodiesChildDiagnosis, DifferentialHumansMaleMeningoencephalitisMethylprednisoloneAutoantibodiesGFAP protein, humanGlial Fibrillary Acidic ProteinMethylprednisoloneglial fibrillary acidic proteininfluenza A virusmeningoencephalitismethylprednisolonequadriplegiarespiratory failure

Identifiers

PMID39924240
PMCPMC12393970

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.