ArticleAmerican journal of ophthalmology2025
Titaminates, a Biocompatible Titanium-Organic Hybrid Film, Support the Growth and Function of Conjunctival Epithelial Cells.
Article in American journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo find an ideal biosurface to regenerate conjunctival epithelium.
designExperimental study.
methodsPieces of human cadaveric conjunctival epithelium removed of connective tissues were randomly placed on 8 different biosurfaces to grow primary conjunctival epithelial cells for 9 to 14 days until the fastest growing cultures covered 80% to 90% of the film surface. Main outcome measures were growth, proliferation capacity, startification, mucin 5AC (MUC5AC) secretion, and compositional balance in cell types.
resultsAll titanium-based films (titaminates) supported the growth, stratification, proliferation, and MUC5AC secretion function of human primary conjunctival epithelial cells (HCjECs), but none of the zinc-based films grew cells at all. Although HCjECs' ability to proliferate, stratify, and secrete MUC5AC per unit cell area was similar across all titaminates, titanium dioxide (TiO
conclusionsGiven the body-friendly nature and clinically proven safety and efficacy of titanium, titaminates TiO
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