Evidence map›Paper›PMID 39924120›Full record

ArticleThe Journal of allergy and clinical immunology2025

Biomarkers of inflammation associated with radon exposure in the School Inner-City Asthma Study (SICAS).

Tina M Banzon, Youn Soo Jung, Kimberly F Greco, Longxiang Li, Kari Nadeau, Perdita Permaul, Petros Koutrakis, Jonathan M Gaffin, Wanda Phipatanakul

Abstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Indoor Radon Exposure Among Schoolchildren: A Systematic Review of Risk Factors.International journal of environmental research and public health · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tina M BanzonDivision of Allergy and Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Youn Soo JungDepartment of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass.
Kimberly F GrecoInstitutional Centers for Clinical and Translational Research, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Longxiang LiDepartment of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Ga.
Kari NadeauDepartment of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass.
Perdita PermaulDivision of Pulmonology, Allergy, and Immunology, Weill Cornell Medicine/New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY.
Petros KoutrakisDepartment of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass.
Jonathan M GaffinDivision of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Wanda PhipatanakulDivision of Allergy and Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass. Electronic address: wanda.phipatanakul@childrens.harvard.edu.

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
MOLECULAR BASIS OF ALLERGIC AND IMMUNOLOGIC DISEASET32AI007512 · NIAID · CHILDREN'S HOSPITAL BOSTON · PI Janet Chou, Peter A Nigrovic · 1996 to 2026
$13.1M
SICAS- Diversity SupplementU01AI110397 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2015 to 2020
$8.8M
ALLERGENS IN INNER-CITY SCHOOLS AND CHILDHOOD ASTHMAR01AI073964 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2008 to 2012
$4.6M
Indoor Air Quality and Respiratory Morbidity in School-Aged Children with Bronchopulmonary DysplasiaR01ES030100 · NIEHS · BOSTON CHILDREN'S HOSPITAL · PI GAFFIN, JONATHAN MARK · 2019 to 2023
$3.7M
Novel NOTCH4 Pathway of Asthma Severity in Urban School Children: Clinical Research Center, Boston Children’s HospitalU01AI160087 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Talal Amine Chatila, WANDA PHIPATANAKUL · 2021 to 2026
$2.8M
Midcareer Investigator Award: Urban School Allergen Exposures and Childhood AsthmK24AI106822 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2013 to 2022
$1.9M
Evaluation of radon progeny and air pollution effects in asthmaK23ES035459 · NIEHS · BOSTON CHILDREN'S HOSPITAL · PI Tina Banzon · 2023 to 2026
$830k
Estimating acute impacts of unconventional oil and gas development on cause-specific hospitalization via satellite-based exposure assessmentR00ES034459 · NIEHS · EMORY UNIVERSITY · PI Longxiang Li · 2024 to 2026
$747k
Estimating acute impacts of unconventional oil and gas development on cause-specific hospitalization via satellite-based exposure assessmentK99ES034459 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI LI, LONGXIANG · 2022 to 2023
$204k
NCATS NIH HHS UL1 TR001102NIAID NIH HHS K24 AI106822NIAID NIH HHS R01 AI073964NIAID NIH HHS T32 AI007512NIAID NIH HHS U01 AI110397NIAID NIH HHS U01 AI160087NIEHS NIH HHS K23 ES035459NIEHS NIH HHS K99 ES034459NIEHS NIH HHS R00 ES034459NIEHS NIH HHS R01 ES030100
6 · The paper itself

Abstract

backgroundRadon is an omnipresent radioactive gas recently reported to be associated with increased asthma morbidity.

objectivesWe aimed to identify biomarkers associated with radon exposure and hypothesized elevated radon exposure to be associated with increased inflammatory biomarker levels in an exploratory analysis.

methodsIn 137 schoolchildren with asthma in the School Inner-City Asthma Study, we assessed estimated radon exposure (1-month averaged radon) by a spatiotemporal model and 46 inflammatory biomarker outcomes, adjusting for copollutants (particulate matter with diameter ≤2.5 μm, NO

resultsIn a total of 137 observations, we found a positive association with radon exposure and IL-5, a T

conclusionsRadon is a potential novel, modifiable risk factor for asthma recently reported to be associated with asthma morbidity. This work identifies important biological disease pathways via biomarkers that may be central to the exposure-outcome relationship.

Indexed as

AsthmaEnvironmental ExposureInflammationRadonAdolescentBiomarkersChildEosinophilsFemaleHumansInterleukin-5MaleSchoolsBiomarkersInterleukin-5RadonAsthmabiomarkerenvironmental exposureeosinophilsIL-5mediation analysisobstructive lung diseaseradon

Identifiers

PMID39924120
PMCPMC12145270

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.