Evidence map›Paper›PMID 39923569›Full record

ArticleEcotoxicology and environmental safety2025

Nrf2/cyclooxygenase 2 signaling in Cr(VI)-induced carcinogenesis.

Lei Zhao, Yi-Fang Wang, Andrea Adamcakova-Dodd, Peter S Thorne, Ranakul Islam, Ke Jian Liu, Fei Chen, Jia Luo, Ling-Zhi Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ecotoxicology and environmental safety, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lei ZhaoDepartment of Pathology, University of Iowa, Iowa, IA 52242, USA; Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Yi-Fang WangDepartment of Pathology, University of Iowa, Iowa, IA 52242, USA; Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Andrea Adamcakova-DoddDepartment of Occupational and Environmental Health, University of Iowa, Iowa City, IA, 52242, USA.
Peter S ThorneDepartment of Occupational and Environmental Health, University of Iowa, Iowa City, IA, 52242, USA.
Ranakul IslamDepartment of Pathology, University of Iowa, Iowa, IA 52242, USA; Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Ke Jian LiuDepartment of Pathology, Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA.
Fei ChenDepartment of Pathology, Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA.
Jia LuoDepartment of Pathology, University of Iowa, Iowa, IA 52242, USA.
Ling-Zhi LiuDepartment of Pathology, University of Iowa, Iowa, IA 52242, USA; Department of Pathology, Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address: Lingzhi.liu2003@yahoo.com.

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
New Mechanism of Arsenic CarcinogenesisK02ES029119 · NIEHS · UNIVERSITY OF IOWA · PI LIU, LING-ZHI · 2018 to 2022
$613k
NIEHS NIH HHS K02 ES029119NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Long-term exposure to hexavalent chromium [Cr(VI)] has been linked to lung cancer, and cyclooxygenase-2 (COX-2) is a well-known inflammatory factor. However, the role and mechanism of COX-2 in Cr(VI)-induced carcinogenesis are not clear yet. To address this question, we employed a mouse model exposed to Cr(VI) through intranasal instillation of particulate zinc chromate (ZnCrO

Indexed as

CarcinogenesisChromiumCyclooxygenase 2Lung NeoplasmsNF-E2-Related Factor 2AnimalsHumansMiceSignal TransductionChromiumchromium hexavalent ionCyclooxygenase 2Nfe2l2 protein, mouseNF-E2-Related Factor 2Ptgs2 protein, mouseCarcinogenesisCOX-2Cr(VI)miR-379Nrf2

Identifiers

PMID39923569
PMCPMC12439351

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.