SynthesisWorld journal of emergency surgery : WJES2025
Diagnostic value of the appendicitis inflammatory response (AIR) score. A systematic review and meta-analysis.
Synthesis in World journal of emergency surgery : WJES, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07370896 (The Alvarado Score in the Emergency Department of Hospitals in the Meta Department, Colombia. A Cross-sectional Study), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Alvarado Score in the Emergency Department of Hospitals in the Meta Department, Colombia. A Cross-sectional Study
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic Accuracy of Non-Contrast CT for Acute Appendicitis in the Emergency Department: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Diagnostic agreement between emergency medicine residents after dedicated appendix ultrasound training and radiologists in the ultrasonographic evaluation of suspected acute appendicitis.Emergency radiology · 2026Article
- A Century of Post-Traumatic Appendicitis: A Comprehensive Review with an Illustrative Case.Pediatric reports · 2026Article
- Article
- Accuracy of the Alvarado Score in Diagnosing Appendicitis Among Children Versus Adults.Cureus · 2026Article
- Appendicitis inflammatory response versus pediatric appendicitis score for grading disease severity in children.Scientific reports · 2026Observational
- CLR (CRP to Lymphocytes) Score for Differentiating Simple and Complicated Appendicitis in Pediatric Patients.Journal of clinical medicine · 2026Article
- Comparison of physical examination, laboratory and radiologic findings in the diagnosis of acute appendicitis.Northern clinics of Istanbul · 2026Article
- Negative Appendectomy Rates and Their Correlation With the Use of Histopathology: A Clinical Audit.Cureus · 2026Article
- Artificial intelligence in acute appendicitis: A comprehensive review of machine learning and deep learning applications.World journal of gastroenterology · 2025Review
- Predictive value of the HALP score in differentiating complicated and uncomplicated acute appendicitis.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025Article
- Incidence and Risk Factors for Post-Appendectomy Emergency Surgical Site Infections.Bulletin of emergency and trauma · 2025Article
- The CHANSE score: a novel clinical tool incorporating the heel drop test for the diagnosis of pediatric appendicitis.Frontiers in pediatrics · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical scoring algorithms are cost efficient in patients with suspicion of acute appendicitis. This is a systematic review and meta-analysis of the diagnostic properties of the Appendicitis Inflammatory Response (AIR) score compared with the Alvarado score.
methodsThe PubMed, EMBASE, Web of Science and Google Scholar databases were searched for reports on the diagnostic properties of the AIR score from 2008 to July 18, 2024. A meta-analysis of the receiver operating characteristic (ROC) area and the sensitivity and specificity for all and advanced appendicitis patients was performed. Advanced appendicitis was defined as perforated or gangrenous appendicitis or appendicitis abscess or phlegmon or if described as complicated appendicitis. The risk of bias was estimated via the QUADAS-2 tool. The ROC areas of the AIR score and the Alvarado score were compared.
resultsA total of 26 reports with a total of 15.699 patients were included. The area under the ROC curve for the AIR score was 0.86 (95% CI 0.83-0.88) for all patients with appendicitis and 0.93 (CI 0.91-0.96) for those with advanced appendicitis, which was greater than the corresponding areas for the Alvarado score (0.79, CI 0.76; 0.81) and 0.88, CI 0.82; 0.95), respectively. At > 4 points, the sensitivity was 0.91 (CI 0.88; 0.94) for all patients with appendicitis and 0.95 (CI 0.94; 0.97) for those with advanced appendicitis. At > 3 points, the sensitivity was 0.95 (0.90; 0.97) for all patients with appendicitis and 0.99 (0.97; 0.99) for those with advanced appendicitis. At > 8 points, the specificity was 0.98 (0.97; 0.99) for all patients with appendicitis and 0.99 (0.97; 0.99) for those with advanced appendicitis. The included studies had a low risk for bias and low heterogeneity.
conclusionThe AIR score has a better diagnostic capacity than the Alvarado score does. The AIR score is a safe and efficient basis for risk-stratified management of patients suspected of having appendicitis.
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