Evidence map›Paper›PMID 39923038›Full record

ArticleBMC oral health2025

Size-controllable synthesis of hydroxyapatite nanorods via fluorine modulation: applications in dental adhesives for enhanced enamel remineralization.

Linzhi Meng, Mengmeng Shu, Peng Mei, Yakun Liang, Lunguo Xia

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Linzhi MengDepartment of Orthodontics, Shanghai Ninth People's Hospital, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200125, China.
Mengmeng ShuDepartment of Orthodontics, Shanghai Ninth People's Hospital, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200125, China.
Peng MeiDepartment of Orthodontics, Shanghai Ninth People's Hospital, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200125, China.
Yakun LiangShanghai Institute of Precision Medicine, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200125, China.
Lunguo XiaDepartment of Orthodontics, Shanghai Ninth People's Hospital, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200125, China. xialunguo@hotmail.com.

Funding

Innovative Research Team of High-level Local University in Shanghai SHSMU-ZLCX20212402National Key Research and Development Program of China 2022YFC2405904National Natural Science Foundation of China 32171348
6 · The paper itself

Abstract

backgroundThere has been little application of fluorine-substituted hydroxyapatites (FHAs) in dental adhesives. Previous studies primarily focused on the effect of fluoride content on enamel remineralization, neglecting the role of FHA particle size. This study aimed to synthesize uniform FHA nanorods of varying sizes by adjusting the fluorine doping levels, and to investigate the synergistic effects of the fluorine content and nanorod size on enamel remineralization by incorporating the FHA nanorods into adhesives.

methodsFHA nanorods with varying fluorine doping levels and sizes were synthesized based on a hydrothermal method. The characterization analyses of FHA nanorods were demonstrated by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). The composite adhesives containing 10 wt% different FHA nanorods were characterized via scanning electron microscopy (SEM). The colloidal stability, light-curing poperties, and degree of conversion (DC %) were assessed. The shear bond strength (SBS) was determined and the failure mode analysis was reported. The release of Ca

resultsUniform FHA nanorods of varying sizes were synthesized by adjusting the fluorine doping level (2 wt%, 6 wt%, and 10 wt%). The lengths of these FHA nanorods were 505.31 ± 104.43 nm, 111.27 ± 22.89 nm, and 66.21 ± 12.68 nm, respectively. The composite adhesives containing FHA nanorods showed good colloidal stability and appropriate light-curing properties. The SBS of composite adhesives decreased due to the incorporation of FHA nanorods, but the values still remained within the clinically required range. Three groups of the composite adhesives could release Ca

conclusionsThe strategy of adding the synthesized FHA nanorods into dental adhesives can be an effective approach to promote enamel remineralization, while maintaining adequate bond strength. The 10 wt% F-doped HA nanorods with shorter lengths exhibited superior remineralization.

Indexed as

Dental CementsDental EnamelDurapatiteFluorineNanotubesTooth RemineralizationMaterials TestingMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionParticle SizeSpectroscopy, Fourier Transform InfraredX-Ray DiffractionDental CementsDurapatiteFluorineDental adhesivesEffect of sizeFluorine-substituted hydroxyapatiteRemineralizationShear bond strengthSize-controllable synthesis

Identifiers

PMID39923038
PMCPMC11806586

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.