Evidence map›Paper›PMID 39922921›Full record

ArticleCommunications biology2025

TEFM facilitates transition from RNA synthesis to DNA synthesis at H-strand replication origin of mtDNA.

Shigeru Matsuda, Masunari Nakayama, Yura Do, Takashi Ishiuchi, Mikako Yagi, Sjoerd Wanrooij, Kazuto Nakada, Fan-Yan Wei, Kenji Ichiyanagi, Hiroyuki Sasaki and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shigeru MatsudaDepartment of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka-shi, Fukuoka, Japan.
Masunari NakayamaDepartment of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka-shi, Fukuoka, Japan.
Yura DoDepartment of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka-shi, Fukuoka, Japan.
Takashi IshiuchiDivision of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University, Fukuoka-shi, Fukuoka, Japan.ORCID http://orcid.org/0000-0001-8346-4596
Mikako YagiDepartment of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka-shi, Fukuoka, Japan.
Sjoerd WanrooijDepartment of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0001-6126-4382
Kazuto NakadaInstitute of Life and Environmental Sciences, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan.
Fan-Yan WeiDepartment of Modomics Biology and Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai-shi, Miyagi, Japan.ORCID http://orcid.org/0000-0002-4843-724X
Kenji IchiyanagiDepartment of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya-shi, Aichi, Japan.
Hiroyuki SasakiDivision of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University, Fukuoka-shi, Fukuoka, Japan.ORCID http://orcid.org/0000-0001-8239-8275
Dongchon KangDepartment of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka-shi, Fukuoka, Japan.
Takehiro YasukawaDepartment of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka-shi, Fukuoka, Japan. t.yasukawa.vb@juntendo.ac.jp.ORCID http://orcid.org/0000-0001-9531-8780

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) JP20H00530
6 · The paper itself

Abstract

Transcription of human mitochondrial DNA (mtDNA) begins from specific transcription promoters. In strand-asynchronous mtDNA replication, transcripts from the light-strand promoter serve as primers for leading-strand synthesis at the origin of the H-strand replication (O

Indexed as

DNA, MitochondrialDNA ReplicationMitochondrial ProteinsReplication OriginRNATranscriptional Elongation FactorsHumansMitochondriaPromoter Regions, GeneticTranscription FactorsTranscription, GeneticDNA, MitochondrialMitochondrial ProteinsRNATEFM protein, humanTranscriptional Elongation FactorsTranscription Factors

Identifiers

PMID39922921
PMCPMC11807126

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.