Evidence map›Paper›PMID 39922919›Full record

Observational studyScientific reports2025

Triglyceride-glucose index is associated with microcirculatory resistance in patients with type 2 diabetes and STEMI undergoing primary PCI.

Guoyu Wang, Cen Xu, Jian Wang, Zhimei Teng, Xiang Sha, Kai Xu, Ruzhu Wang, Li Zhu

Abstract readObservational Study
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guoyu WangDepartment of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, 366 Taihu Road, Hailing District, Taizhou, 225300, Jiangsu, People's Republic of China.
Cen XuDepartment of Reproductive Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, People's Republic of China.
Jian WangDepartment of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, 366 Taihu Road, Hailing District, Taizhou, 225300, Jiangsu, People's Republic of China.
Zhimei TengDepartment of Nosocomial Infection Management, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, People's Republic of China.
Xiang ShaDepartment of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, 366 Taihu Road, Hailing District, Taizhou, 225300, Jiangsu, People's Republic of China.
Kai XuDepartment of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, 366 Taihu Road, Hailing District, Taizhou, 225300, Jiangsu, People's Republic of China.
Ruzhu WangDepartment of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, 366 Taihu Road, Hailing District, Taizhou, 225300, Jiangsu, People's Republic of China.
Li ZhuDepartment of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, 366 Taihu Road, Hailing District, Taizhou, 225300, Jiangsu, People's Republic of China. 715327453@qq.com.

Funding

the clinical research project of Taizhou clinical college of medicine of Nanjing Medical University TZKY20230207
6 · The paper itself

Abstract

The triglyceride-glucose (TyG) index is emerging as a promising marker for insulin resistance and serves as an independent risk predictor for cardiovascular outcomes. The coronary angiography-derived index of microcirculatory resistance (AMR) is computed to evaluate coronary microcirculation. However, the association between the TyG index and the AMR in patients with type 2 diabetes mellitus (T2DM) and ST-segment elevation myocardial infarction (STEMI) remains unclear. We consecutively recruited 168 patients with T2DM and STEMI who underwent primary percutaneous coronary intervention (pPCI) at Taizhou People's Hospital from January 2022 to December 2023. Patients were classified into low AMR group (AMR < 2.5) and high AMR group (AMR ≥ 2.5). The TyG index was calculated using the formula: ln [plasma triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2]. The study enrolled 81 patients in the low AMR group and 87 in the high AMR group, with the TyG index being significantly higher in the high AMR group. Multivariable logistic regression analysis revealed a significant association between the TyG index and high AMR after adjusting for confounding variables (odds ratio: 2.449, 95% confidence interval: 1.421-4.220, and p = 0.001). The area under the curve for the TyG index predicting high AMR was 0.650 (95% confidence interval: 0.57-0.73, p < 0.001), with a cut-off value of 9.57. Our findings indicate that the TyG index is significantly associated with AMR in T2DM patients with STEMI undergoing pPCI, suggesting it may serve as a valuable predictor of high AMR in this population.

Indexed as

Blood GlucoseDiabetes Mellitus, Type 2MicrocirculationPercutaneous Coronary InterventionST Elevation Myocardial InfarctionTriglyceridesAgedBiomarkersCoronary AngiographyFemaleHumansInsulin ResistanceMaleMiddle AgedRisk FactorsBiomarkersBlood GlucoseTriglyceridesAngiography-based index of coronary microcirculatory resistanceST-segment elevation myocardial infarctionTriglyceride-glucose index

Identifiers

PMID39922919
PMCPMC11807154

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.