Evidence map›Paper›PMID 39922888›Full record

ArticleScientific reports2025

Development of highly bioactive long-acting recombinant porcine FSH for batch production management of sows.

Jiawei Zhang, Lei Shi, Xiaorong Zhong, Yunhe Bai, Jun Dou, Lu Zhang, Xiaochao Shi, Bingchun Wu, Zemin Tan, Lin Yan and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jiawei ZhangBeijing VJTBio Co., LTD, Beijing, 100085, China.
Lei ShiBeijing VJTBio Co., LTD, Beijing, 100085, China.
Xiaorong ZhongBeijing VJTBio Co., LTD, Beijing, 100085, China.
Yunhe BaiBeijing VJTBio Co., LTD, Beijing, 100085, China.
Jun DouBeijing VJTBio Co., LTD, Beijing, 100085, China.
Lu ZhangDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Xiaochao ShiBeijing VJTBio Co., LTD, Beijing, 100085, China.
Bingchun WuBeijing VJTBio Co., LTD, Beijing, 100085, China.
Zemin TanBeijing VJTBio Co., LTD, Beijing, 100085, China.
Lin YanBeijing VJTBio Co., LTD, Beijing, 100085, China.
Jinku YuBeijing VJTBio Co., LTD, Beijing, 100085, China.
Jingru ZhangBeijing VJTBio Co., LTD, Beijing, 100085, China.
Guo HanBeijing VJTBio Co., LTD, Beijing, 100085, China.
Jiansheng XiongBeijing VJTBio Co., LTD, Beijing, 100085, China.
Hua ZhangState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, 100193, China.
Xingyuan CaoDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Haoshu LuoBeijing VJTBio Co., LTD, Beijing, 100085, China. vjtpublic@vjtbio.com.

Funding

National Key Research and Development Program of China 2022YFD1300304National Natural Science Foundation of China 32200704
6 · The paper itself

Abstract

To improve the economic benefits, exogenous hormones are used to control follicular development and synchronize ovulation in the batch flow management of gilts and weaned sows. Equine chorionic gonadotropin (eCG) is widely used to stimulate follicular development in both experimental and farm animals. Despite its effectiveness, several side effects have been found, including the occurrence of follicular cysts, follicular premature luteinization, and increased follicular atresia. As eCG is a heterologous protein, the generation of antibodies has been found in the superovulation of cattle. Moreover, the extraction of eCG from pregnant mare serum raises concerns regarding animal welfare, as well as potential risks for disease transmission. Follicle stimulating hormone (FSH) controls the follicular growth and maturation in the porcine ovary under physiological conditions. In the current study, we developed a novel long-acting recombinant porcine FSH (rpFSH-pFc) consisting of porcine FSH and porcine fragment crystallizable (Fc) via (G4S)

Indexed as

Follicle Stimulating HormoneRecombinant ProteinsAnimalsFemaleOvarian FollicleRatsSwineFollicle Stimulating HormoneRecombinant ProteinsEstrous synchronizationFollicular developmentRecombinant FSHReproductive hormoneSwine

Identifiers

PMID39922888
PMCPMC11807123

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.