Evidence map›Paper›PMID 39922849›Full record

ArticleScientific reports2025

Selective epithelial expression of KRAS

Carlos P Jara, Al-Murtadha Al-Gahmi, Audrey Lazenby, Michael A Hollingsworth, Mark A Carlson

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Carlos P JaraDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0001-5444-721X
Al-Murtadha Al-GahmiDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0009-0000-5484-467X
Audrey LazenbyDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.
Michael A HollingsworthEppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-5255-8888
Mark A CarlsonDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE, USA. macarlso@unmc.edu.ORCID 0000-0002-8113-9199

Funding

Pancreatic Cancer Detection ConsortiumU01CA210240 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Michael A. Hollingsworth · 2017 to 2026
$12.9M
Development and Application of a Porcine Model of Pancreatic CancerR01CA222907 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CARLSON, MARK A · 2018 to 2020
$1.7M
Porcine Platforms For Technology Development In Pancreatic CancerR01CA295693 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Michael A. Hollingsworth, Joshua M.V. Mammen · 2025 to 2026
$1.3M
NCI NIH HHS R01 CA222907NCI NIH HHS R01 CA295693NCI NIH HHS U01 CA210240NIH/NCI R01CA222907
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) remains a formidable challenge in oncology, characterized by a high mortality rate, largely attributable to delayed diagnosis and the intricacies of its tumor microenvironment. Innovations in modeling pancreatic epithelial transformation provide valuable insights into the pathogenesis and potential therapeutic strategies for PDAC. We employed a porcine (Oncopig) model, utilizing the Ad-K8-Cre adenoviral vector, to investigate the effects of variable doses (10

Indexed as

Carcinoma, Pancreatic DuctalPancreatic DuctsPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)AdenoviridaeAnimalsAnimals, Genetically ModifiedCell ProliferationDisease Models, AnimalEpithelial CellsGenetic VectorsHumansKeratin-8PancreasSwineKeratin-8Proto-Oncogene Proteins p21(ras)Ad-K8-CreDesmoplastic reactionKRASG12DNeoplasiaOncopigsPDAC

Identifiers

PMID39922849
PMCPMC11807195

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.