Evidence map›Paper›PMID 39922838›Full record

ArticleScientific reports2025

Anthelmintic activity of 1,10-phenanthroline-5,6-dione-based metallodrugs.

Maria E Cirino, Thainá R Teixeira, Alessandro M H Silva, Ana C C Borges, Lucas Fukui-Silva, Luis G Wagner, Christiane Fernandes, Malachy McCann, André L S Santos, Josué de Moraes

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Antischistosomal activity of imidazolidine-2,4-dione derivatives.Antimicrobial agents and chemotherapy · 2026
    Article
  8. Review
  9. Acetylene Acetogenin fromACS omega · 2025
    Article
  10. Article
  11. Phenotypic Screening of HPharmaceuticals (Basel, Switzerland) · 2025
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maria E CirinoNúcleo de Pesquisas em Doenças Negligenciadas, Universidade Guarulhos, Guarulhos, SP, 07023‑070, Brazil.
Thainá R TeixeiraNúcleo de Pesquisas em Doenças Negligenciadas, Universidade Guarulhos, Guarulhos, SP, 07023‑070, Brazil.
Alessandro M H SilvaNúcleo de Pesquisas em Doenças Negligenciadas, Instituto Científico e Tecnológico, Universidade Brasil, São Paulo, SP, 08230-030, Brazil.
Ana C C BorgesNúcleo de Pesquisas em Doenças Negligenciadas, Universidade Guarulhos, Guarulhos, SP, 07023‑070, Brazil.
Lucas Fukui-SilvaNúcleo de Pesquisas em Doenças Negligenciadas, Universidade Guarulhos, Guarulhos, SP, 07023‑070, Brazil.
Luis G WagnerDepartamento de Química, Universidade Federal de Santa Catarina, Santa Catarina, SC, 88040- 900, Brazil.
Christiane FernandesDepartamento de Química, Universidade Federal de Santa Catarina, Santa Catarina, SC, 88040- 900, Brazil.
Malachy McCannDepartment of Chemistry, Maynooth University, National University of Ireland, Maynooth, W23 F2H6, Ireland.
André L S SantosLaboratório de Estudos Avançados de Microrganismos Emergentes e Resistentes, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.
Josué de MoraesNúcleo de Pesquisas em Doenças Negligenciadas, Universidade Guarulhos, Guarulhos, SP, 07023‑070, Brazil. moraesnpdn@gmail.com.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/08418-6
6 · The paper itself

Abstract

Parasitic worm infections impose a significant public health burden, affecting over 2 billion people, particularly in low-income regions. The limited efficacy of current treatments highlights the urgent need for new anthelmintic agents. This study investigates the potential antiparasitic activity of 1,10-phenanthroline-5,6-dione (phendione) and its metal complexes, [Cu(phendione)

Indexed as

AnthelminticsCoordination ComplexesPhenanthrolinesAnimalsCaenorhabditis elegansChlorocebus aethiopsHumansSchistosoma mansoniVero CellsAnthelminticsCoordination ComplexesPhenanthrolines

Identifiers

PMID39922838
PMCPMC11807182

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.