ArticleThe journal of prevention of Alzheimer's disease2025
The interaction between circadian syndrome and genetic susceptibility in the risk of incident dementia: A longitudinal cohort study.
Article in The journal of prevention of Alzheimer's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The influence of physical activity on circadian syndrome: a nationwide prospective study based on the CHARLS cohort.BMC public health · 2026Article
- Circadian syndrome (CircS) and cognitive trajectory deterioration in middle-aged and older adults: A national cohort study with causal forest analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Associations of adherence to a healthy sleep pattern with the dementia risk in the UK biobank.Alzheimer's research & therapy · 2025Article
- Mitochondrial dysfunction as the missing link between circadian syndrome and dementia.The journal of prevention of Alzheimer's disease · 2025Article
- Reply to: Mitochondrial dysfunction as the missing link between circadian syndrome and dementia.The journal of prevention of Alzheimer's disease · 2025Article
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Authors and funding
7 authors.
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Abstract
backgroundDespite growing interest in circadian disturbances as potential triggers for dementia, the specific impact of circadian syndrome (CircS) on dementia incidence remains poorly understood. Moreover, the role of genetic susceptibility modulating these effects remains to be explored.
methodsDementia-free participants from the UK Biobank cohort were included in the analysis. To evaluate the association between CircS and the incidence of dementia, as well as the modifying influence of genetic susceptibility on this relationship, Cox proportional hazards models were utilized.
resultsDuring a median follow-up period of 14.55 years, 3,965 incident dementia cases were documented. CircS was found to significantly increased the risk of incident dementia, with a hazard ratio (HR) of 1.401 (95 % confidence interval [CI]: 1.296, 1.516). Compared to a CircS score of ≤3, mild CircS (HR: 1.259, 95 % CI: 1.146-1.383), moderate CircS (HR: 1.667, 95 % CI: 1.461-1.903), and severe CircS (HR: 2.028, 95 % CI: 1.397-2.944) were all significantly associated with an elevated risk of dementia. There were significant multiplicative interactions between CircS and genetic susceptibility (P
conclusionsCircS was associated with an increased risk of dementia, which might be aggravated by genetic susceptibility.
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