Evidence map›Paper›PMID 39922483›Full record

ArticleMicrovascular research2025

Feasibility of a method for measurement of retinal pulse-propagated wave velocity in humans.

Zhengxin Tang, Anthony E Felder, Mahnaz Shahidi

Abstract read
In one paragraph

Article in Microvascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhengxin TangCollege of Medicine, University of Illinois Chicago, Chicago, IL, USA; Richard and Loan Hill Department of Biomedical Engineering, University of Illinois Chicago, Chicago, IL, USA. Electronic address: ztang26@uic.edu.
Anthony E FelderRichard and Loan Hill Department of Biomedical Engineering, University of Illinois Chicago, Chicago, IL, USA. Electronic address: afelde2@uic.edu.
Mahnaz ShahidiDepartment of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA. Electronic address: mshahidi@usc.edu.

Funding

Ophthalmic Therapeutics Engineering CoreP30EY029220 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Mahnaz Shahidi · 2018 to 2026
$6.5M
Imaging of Retinal Oxygen Metabolism in Diabetic RetinopathyR01EY030115 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHAHIDI, MAHNAZ · 2020 to 2024
$2.0M
NEI NIH HHS P30 EY029220NEI NIH HHS R01 EY030115
6 · The paper itself

Abstract

Blood flow regulation has been shown to be compromised in common ocular diseases, such as diabetic retinopathy and glaucoma. The capacity of the retinal vessels to regulate blood flow can potentially serve as an oculomics biomarker for evaluating ocular and systemic diseases. Pulse-propagated intravascular pressure waves cause deformations of the vessel walls, thus offering a means to interrogate vascular compliance. The purpose of the current study is to report a method for measuring retinal pulse-propagated wave velocity (rPWV) based on spectral analysis of pulsatile intensity waveforms in human circumpapillary retinal vasculature. Arterial and venous rPWV values, as well as inter-subject variabilities of rPWV in non-diabetic and diabetic subjects, are reported. Preliminary results demonstrated the feasibility of this method for measuring rPWV and its potential for assessment of vascular plasticity in response to blood flow changes due to ocular and systemic diseases.

Indexed as

Diabetic RetinopathyPulsatile FlowPulse Wave AnalysisRetinal ArteryRetinal VeinRetinal VesselsAdultBlood Flow VelocityCase-Control StudiesFeasibility StudiesFemaleHumansMaleMiddle AgedPredictive Value of TestsRegional Blood FlowImagingPulse wave velocityRetina

Identifiers

PMID39922483
PMCPMC11908900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.