Evidence map›Paper›PMID 39921824›Full record

Trial reportObesity surgery2025

Comparison between low molecular weight heparin and apixaban (direct oral anticoagulant) in the prophylaxis against venous thromboembolism after laparoscopic sleeve gastrectomy.

Ahmed Abdelsalam, Michael Fikry, Ahmed Fahmy, Tarek Hegazy, Afaf Hamdy, Ahmed Refaat, Ahmed Elansary

Abstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ahmed AbdelsalamGeneral Surgery Department, Faculty of Medicine, Cairo University, Giza, Egypt. a.abd.elsalam@kasralainy.edu.eg.
Michael FikryGeneral Surgery Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Ahmed FahmyGeneral Surgery Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Tarek HegazyGeneral Surgery Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Afaf HamdyDiagnostic and Interventional Radiology Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Ahmed RefaatGeneral Surgery Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Ahmed ElansaryGeneral Surgery Department, Faculty of Medicine, Cairo University, Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLike any major operation, sleeve gastrectomy (SG) has its reported postoperative complications. Among them are venous thromboembolic complications (VTE) that may predispose to mortality. Despite the proven efficacy of the traditional anticoagulants, such as low molecular weight heparins (LMWHs) for VTE management, they have their limitations. Direct oral anticoagulants (DOACs) have been currently adopted for the management of VTE. We conducted this study to evaluate the efficacy and safety of apixaban against VTE after laparoscopic sleeve gastrectomy in comparison with LMWH.

methodsThis was a randomized controlled trial that included 100 adult patients who underwent SG and received LMWH (Group A) or apixaban (Group B) for VTE prophylaxis. We recorded and analyzed the postoperative events up to the 30th day after surgery.

resultsThis study included Group A (n = 50) and Group B (n = 50). No VTE occurred in either group (0%). Postoperative bleeding was encountered in one patient of each group (2%). The follow-up venous Doppler study was unremarkable in the two groups.

conclusionApixaban was shown to be comparable to LMWH for the prevention of VTE after LSG with similar efficacy and safety making it a promising alternative to LMWH in patients undergoing bariatric surgery.

Indexed as

Factor Xa InhibitorsGastrectomyHeparin, Low-Molecular-WeightObesity, MorbidPostoperative ComplicationsPyrazolesPyridonesVenous ThromboembolismAdministration, OralAdultAnticoagulantsFemaleHumansLaparoscopyMaleMiddle AgedAnticoagulantsapixabanFactor Xa InhibitorsHeparin, Low-Molecular-WeightPyrazolesPyridonesApixabanBariatric surgeryDirect oral anticoagulantsVenous thromboembolic complications

Identifiers

PMID39921824
PMCPMC11906520

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.