ReviewMetabolic brain disease2025
Gut microbiota-derived short chain fatty acids act as mediators of the gut-liver-brain axis.
Review in Metabolic brain disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring the molecular mechanisms by which exercise improves cognitive impairment in Parkinson's disease based on the brain-gut microbiota axis: bibliometrics and visualization analysis.Frontiers in microbiology · 2026Pooled it
- Two-sample Mendelian randomization study of gut microbiota and inflammatory proteins: Predictive, preventive, and personalized treatment for migraine.Neural regeneration research · 2026Article
- Dietary Fat Intake and Its Influence on the Association Between Liver Fat and Brain Choline Metabolism in Young Saudi Women.Saudi medical journal · 2026Article
- The impact of microbial metabolites on host chromatin and epigenetic regulation.Nature metabolism · 2026Review
- Article
- Physicochemical Properties and Gut Microbiota-Regulating Activities of Macromolecules from Fresh and Dried BiyangNutrients · 2026Article
- Review
- Nervonic Acid Prevents HFD-Induced Metabolic Dysfunction and Is Associated with Gut Microbiota Remodeling.Metabolites · 2026Article
- Review
- Rumen unprotected glucose tends to promote intramuscular fat deposition via microbial volatile fatty acid-mediated metabolic reprogramming in cattle: a multi-omics perspective through the rumen-jejunum axis.Journal of animal science and biotechnology · 2026Article
- Travel-Induced Circadian and Microbiota Disturbances: Implications for Athlete Health and Performance: A Narrative Review.Nutrients · 2026Review
- BPA Disrupts Hepatic Lipid and Carbohydrate Metabolism in Female Zebrafish: Protective Effects of Probiotics Revealed by FTIRI and Lipidomics.International journal of molecular sciences · 2026Article
- Bacterial Extracellular Vesicles in the Pathogenesis and Treatment of Liver Diseases.Journal of gastroenterology and hepatology · 2026Review
- Gut microbiota-epigenetic interactions in systemic aging: mechanistic drivers for endocrine and reproductive network remodeling and therapeutic modulation.Frontiers in aging · 2026Review
- Advances in understanding intestinal microbiota mechanisms and intervention strategies for anxiety, depression, sleep disorders, and constipation.Frontiers in microbiology · 2026Review
- Composition of and changes in faecal microbiota in children diagnosed with oligoarticular juvenile idiopathic arthritis.Frontiers in medicine · 2026Article
- Microbiota-innate immune crosstalk drives atherosclerosis: mechanisms, disease progression, and emerging therapeutic strategies.Frontiers in immunology · 2026Review
- Lipidomic Signatures in Pediatric Metabolic Disorders.Metabolites · 2025Review
- The protective effect of probiotic therapy on gut microbiota and the activation of ω-oxidation after ovarian cancer surgery.Journal of cancer research and clinical oncology · 2025Article
- Integrative Neuroimmune Role of the Parasympathetic Nervous System, Vagus Nerve and Gut Microbiota in Stress Modulation: A Narrative Review.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiota plays a crucial role in the communication between the gut, liver, and brain through the production of short chain fatty acids (SCFAs). SCFAs serve as key mediators in the Gut-Liver-Brain Axis, influencing various physiological processes and contributing to overall health. SCFAs are produced by bacterial fermentation of dietary fiber in the gut, and they exert systemic effects by signaling through various pathways. In the Gut-Liver axis, SCFAs regulate liver metabolism through peroxisome proliferator-activated receptor-γ (PPAR-γ), AMP-activated protein kinase (AMPK) and other pathways, promotes fat oxidation, modulate inflammation through mTOR pathway, and impact metabolic health. In the Gut-Brain axis, SCFAs influence brain function, behavior, and may have implications for neurological disorders, in which G-protein coupled receptors (GPCRs) play an essential role, along with other pathways such as hypothalamic-pituitary-adrenal (HPA) pathway. Understanding the mechanisms by which SCFAs mediate communication between the gut, liver, and brain is crucial for elucidating the complex interplay of the Gut-Liver-Brain Axis. This review aims to provide insight into the role of gut microbiota-derived SCFAs as mediators of the Gut-Liver-Brain Axis and their potential therapeutic implications. Further research in this area will be instrumental in developing novel strategies to target the Gut-Liver-Brain Axis for the prevention and treatment of various health conditions.
Indexed as
Identifiers
39921774What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.