Evidence map›Paper›PMID 39921759›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Evaluation of sarcopenia's relationship with overall survival and treatment toxicity in soft tissue sarcomas.

İlknur Deliktaş Onur, Pınar Özdemir Akdur, Hatice Gülgün Fırat, Elif Sertesen Çamöz, Nazan Çiledağ, Burcu Savran, Fatih Yıldız

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

İlknur Deliktaş OnurDepartment of Medical Oncology, Dr. Abdurrahman Yurtaslan, Ankara Oncology Education and Research Hospital, Health Sciences University, Demetevler, Vatan Street, 06200, Ankara, Turkey. ilknurdeliktas382@gmail.com.
Pınar Özdemir AkdurDepartment of Radiology, Dr. Abdurrahman Yurtaslan, Ankara Oncology Education and Research Hospital, Health Sciences University, Ankara, Turkey.
Hatice Gülgün FıratDepartment of Internal Medicine, Dr. Abdurrahman Yurtaslan, Ankara Oncology Education and Research Hospital, Health Sciences University, Ankara, Turkey.
Elif Sertesen ÇamözDepartment of Medical Oncology, Dr. Abdurrahman Yurtaslan, Ankara Oncology Education and Research Hospital, Health Sciences University, Demetevler, Vatan Street, 06200, Ankara, Turkey.
Nazan ÇiledağDepartment of Radiology, Dr. Abdurrahman Yurtaslan, Ankara Oncology Education and Research Hospital, Health Sciences University, Ankara, Turkey.
Burcu SavranDepartment of Radiology, Dr. Abdurrahman Yurtaslan, Ankara Oncology Education and Research Hospital, Health Sciences University, Ankara, Turkey.
Fatih YıldızDepartment of Medical Oncology, Dr. Abdurrahman Yurtaslan, Ankara Oncology Education and Research Hospital, Health Sciences University, Demetevler, Vatan Street, 06200, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe aim of our study is to evaluate the relationship between sarcopenia, overall survival (OS), and chemotherapy toxicity in patients with unresectable/metastatic soft tissue sarcoma (STS) treated with adriamycin and ifosfamide.

methodsPatients with unresectable/metastatic STS over the age of 18, diagnosed between 2015 and 2023, were included in the study. The study was conducted retrospectively in a single center. Total muscle volume at the lumbar 3 (L3) vertebra level was measured from the patient's computer tomography (CT) images. The skeletal muscle index (SMI) was calculated for each patient. Additionally, the prognostic nutritional index (PNI) was calculated for each patient using blood values.

resultsFifty-eight patients were included in the study. The median age of the patients was 51 years, Thirty-six (62.1%) were female and 22 (37.9%) were male. The SMI median was 49 cm

conclusionsA significant relationship was found between SMI and OS, but no significant relationship was found between PNI and OS. A significant relationship was also detected between SMI and treatment toxicity. Our study reveals that evaluating ECOG PS and sarcopenia in addition to grade and histological subtype when making treatment decisions will be associated with longer survival and less toxicity.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsSarcomaSarcopeniaAdultAgedDoxorubicinFemaleHumansIfosfamideMaleMiddle AgedMuscle, SkeletalNutrition AssessmentPrognosisRetrospective StudiesSurvival RateDoxorubicinIfosfamideAdriamycin and ifosfamide toxicitySarcopeniaSoft tissue sarcomaToxicity

Identifiers

PMID39921759

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