Evidence map›Paper›PMID 39921723›Full record

ArticleCellular and molecular life sciences : CMLS2025

Ketogenic diet induces an inflammatory reactive astrocytes phenotype reducing glioma growth.

Maria Rosito, Javeria Maqbool, Alice Reccagni, Micol Mangano, Tiziano D'Andrea, Arianna Rinaldi, Giovanna Peruzzi, Beatrice Silvestri, Alessandro Rosa, Flavia Trettel and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Gut microbes · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Reactive Astrocytes in Glioma: Emerging Opportunities and Challenges.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maria RositoDepartment of Physiology and Pharmacology, Sapienza University, P.Le Aldo Moro 5, 00185, Rome, Italy. maria.rosito@gmail.com.ORCID http://orcid.org/0000-0002-9968-7767
Javeria MaqboolDepartment of Physiology and Pharmacology, Sapienza University, P.Le Aldo Moro 5, 00185, Rome, Italy.
Alice ReccagniDepartment of Physiology and Pharmacology, Sapienza University, P.Le Aldo Moro 5, 00185, Rome, Italy.
Micol ManganoDepartment of Physiology and Pharmacology, Sapienza University, P.Le Aldo Moro 5, 00185, Rome, Italy.
Tiziano D'AndreaIRCCS Neuromed, Pozzilli, IS, Italy.
Arianna RinaldiDepartment of Physiology and Pharmacology, Sapienza University, P.Le Aldo Moro 5, 00185, Rome, Italy.
Giovanna PeruzziCenter for Life Nanoscience & Neuroscience, Istituto Italiano di Tecnologia@Sapienza, Rome, Italy.
Beatrice SilvestriCenter for Life Nanoscience & Neuroscience, Istituto Italiano di Tecnologia@Sapienza, Rome, Italy.
Alessandro RosaCenter for Life Nanoscience & Neuroscience, Istituto Italiano di Tecnologia@Sapienza, Rome, Italy.
Flavia TrettelDepartment of Physiology and Pharmacology, Sapienza University, P.Le Aldo Moro 5, 00185, Rome, Italy.
Giuseppina D'AlessandroDepartment of Physiology and Pharmacology, Sapienza University, P.Le Aldo Moro 5, 00185, Rome, Italy.
Myriam CatalanoDepartment of Physiology and Pharmacology, Sapienza University, P.Le Aldo Moro 5, 00185, Rome, Italy.
Sergio FucileDepartment of Physiology and Pharmacology, Sapienza University, P.Le Aldo Moro 5, 00185, Rome, Italy.
Cristina LimatolaIRCCS Neuromed, Pozzilli, IS, Italy. cristina.limatola@uniroma1.it.

Funding

EUROPEAN UNION CUP B83C22002820006Fondazione AIRC per la ricerca sul cancro ETS IG-23010MUR MINISTERO UNIVERSITÀ E RICERCA PRIN 2020 Z73J5AMUR MINISTERO UNIVERSITÀ E RICERCA PRIN P2022X5ESCROME TECHNOPOLE ECS 0000024
6 · The paper itself

Abstract

The use of a ketogenic diet (KD) in glioma is currently tested as an adjuvant treatment in standard chemotherapy regimens. The metabolic shift induced by the KD leads to the generation of ketone bodies that can influence glioma cells and the surrounding microenvironment, but the mechanisms have not yet been fully elucidated. Here, we investigated the potential involvement of glial cells as mediators of the KD-induced effects on tumor growth and survival rate in glioma-bearing mice. Specifically, we describe that exposing glioma-bearing mice to a KD or to β-hydroxybutyrate (β-HB), one of the main KD metabolic products, reduced glioma growth in vivo, induced a pro-inflammatory phenotype in astrocytes and increased functional glutamate transporters. Moreover, we described increased intracellular basal Ca

Indexed as

AstrocytesBrain NeoplasmsDiet, KetogenicGliomaInflammation3-Hydroxybutyric AcidAnimalsCalciumCell Line, TumorCell ProliferationMiceMice, Inbred C57BLPhenotype3-Hydroxybutyric AcidCalciumAstrocytesAstrogliosisGliomaKetogenic dietMicrogliaPro-inflammatory astrocytesβ-HB

Identifiers

PMID39921723
PMCPMC11807044

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.