Evidence map›Paper›PMID 39921688›Full record

ArticleMolecular neurobiology2025

Pelargonium graveolens Attenuates Rotenone-Induced Parkinson's Disease in a Rat Model: Role of MAO-B Inhibition and In Silico Study.

Rana M Merghany, Salma A El-Sawi, Asmaa F Aboul Naser, Mohamed A Salem, Shahira M Ezzat, Sherifa F A Moustafa, Meselhy R Meselhy

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rana M MerghanyDepartment of Pharmacognosy, National Research Centre, 33 El Buhouth St, Cairo, 12622, Egypt. rana.merghany@gmail.com.ORCID http://orcid.org/0000-0002-3363-5681
Salma A El-SawiDepartment of Pharmacognosy, National Research Centre, 33 El Buhouth St, Cairo, 12622, Egypt.
Asmaa F Aboul NaserDepartment of Therapeutic Chemistry, National Research Centre, 33 El Buhouth St, Cairo, 12622, Egypt.
Mohamed A SalemDepartment of Pharmacognosy and Natural Products, Faculty of Pharmacy, Menoufia University, Gamal Abd El Nasr St., Shibin El Kom, 32511, Menoufia, Egypt.
Shahira M EzzatDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.
Sherifa F A MoustafaDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.
Meselhy R MeselhyDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt. meselhy.meselhy@pharma.cu.edu.eg.ORCID http://orcid.org/0000-0002-3488-7522

Funding

National Research Centre 12/5/2
6 · The paper itself

Abstract

Parkinson's disease (PD), the second most common neurodegenerative condition, is primarily characterized by motor dysfunctions due to dopaminergic neuronal loss in the Substantia Nigra (SN), with oxidative stress playing a significant role in its progression. This study investigates the neuroprotective potential of Pelargonium graveolens (Thunb.) L'Hér leaves in a rotenone-induced PD rat model. The total ethanolic extract and its fractions, obtained via Diaion HP-20 column chromatography, were evaluated for monoamine oxidase-B (MAO-B) inhibition in vitro. The 50% methanol fraction (PG50) demonstrated the highest MAO-B inhibition (IC

Indexed as

Computer SimulationMonoamine OxidaseMonoamine Oxidase InhibitorsParkinson DiseasePlant ExtractsAnimalsDisease Models, AnimalMaleMolecular Docking SimulationNeuroprotective AgentsOxidative StressRatsRats, Sprague-DawleyRats, WistarRotenoneMonoamine OxidaseMonoamine Oxidase InhibitorsNeuroprotective AgentsPlant ExtractsRotenoneMAO-BNeuro-inflammationOxidative stressParkinson’s diseasePelargonium graveolensα-Synuclein

Identifiers

PMID39921688
PMCPMC12078355

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.