ArticleEchocardiography (Mount Kisco, N.Y.)2025
Increased Afterload in Patients With Acute Reduction in Left Ventricular Ejection Fraction Following Mitral Valve Transcatheter Edge-to-Edge Repair.
Article in Echocardiography (Mount Kisco, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Mitral Transcatheter Edge-to-Edge Repair in Patients With Advanced Heart Failure: A Single-Center Experience and Insights Into Anatomical and Clinical Determinants of Procedural Complexity.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
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Authors and funding
10 authors.
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Abstract
aimThe mechanisms and clinical importance of acute reduction (ARD) in left ventricular (LV) function following transcatheter edge-to-edge repair (TEER) for mitral regurgitation (MR) remains unclear. This study aimed to non-invasively evaluate the cardio-mechanical parameters, including end-systolic elastance (Ees) and arterial elastance (Ea), to explore their association with ARD following mitral TEER. METHODS AND
resultsWe performed a retrospective analysis of serial transthoracic echocardiography (TTE) studies before and after mitral TEER. Cardio-mechanical parameters were evaluated non-invasively using a modified single-beat method. After the exclusion of nine patients requiring intravenous catecholamine infusion, the study cohort comprised 49 consecutive patients (25 men; mean age: 81 ± 9 years) with successful mitral TEER. ARD in LV function was defined as a decrease in LV ejection fraction (LVEF) of ≥5 points following the procedure by TTE, which was reported in 18 patients. The hospitalization period was longer in patients with ARD in LVEF than in those without ARD (5.5 days vs. 4 days, p = 0.031). Following improvement in MR, Ea increased (1.54 ± 0.49 mmHg/mL vs. 1.84 ± 0.55 mmHg/mL, p = 0.004). Linear regression analysis revealed a correlation between Δtotal stroke volume (SV) and ΔEa (r = 0.614, p < 0.0001). Notably, ΔEa was higher in patients with ARD in LVEF than in those without ARD in LVEF (0.60 ± 0.73 mmHg/mL vs. 0.14 ± 0.39 mmHg/mL, p = 0.006).
conclusionARD in LVEF after mitral TEER was reported in a substantial proportion of patients and may have prognostic implications. Evaluating cardio-mechanical parameters may aid in understanding complex hemodynamics and guiding treatment strategies for patients with MR undergoing TEER.
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