Evidence map›Paper›PMID 39921581›Full record

ArticleJournal of diabetes2025

Glucokinase Regulatory Protein as a Putative Target for Gestational Diabetes Mellitus and Related Complications: Evidence From the Mendelian Randomization Study.

Weian Mao, Guiquan Wang, Xiao Wang, Yan Shen, Shuai Yuan, Lin Wang, Haiyan Yang, Yan Li, Kai Chen, Jun Liu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Weian MaoReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Guiquan WangDepartment of Reproductive Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China; Xiamen Key Laboratory of Reproduction and Genetics, Xiamen, China.
Xiao WangDepartment of Obstetrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yan ShenThe First School of Medicine, Wenzhou Medical University, Wenzhou, China.
Shuai YuanUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Lin WangReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Haiyan YangReproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yan LiReproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Kai ChenCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Jun LiuNuffield Department of Population Health, University of Oxford, Oxford, UK.
Xi DongReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Yue ZhaoCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Liangshan MuReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-2498-3825

Funding

National Key Research and Development Program of China 2021YFC2700402National Natural Science Foundation of China 82401908National Natural Science Foundation of China 82471670
6 · The paper itself

Abstract

backgroundGestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and is highly associated with adverse perinatal outcomes and long-term health problems for the mother and offspring. However, there are respective limitations in the pharmacological strategies for the current treatment of GDM. Glucokinase regulatory protein (GCKR) has been associated with GDM in observational studies and animal experiments and thus represents a potential drug target of interest for investigation.

methodsWe applied two-sample Mendelian randomization (MR) and colocalization analysis using summary-level data from genome-wide association studies of GCKR and GDM. Two-step MR was used to explore the mediating effects of several metabolic factors on the association. We also applied MR to explore the associations of GCKR levels with GDM-related outcomes. Finally, we performed a phenome-wide association study (PheWAS) to query the potential effects of altered GCKR levels across multiple health categories.

resultsWe found a significant association between elevated GCKR levels and GDM (OR = 3.466, 95% CI = 2.401-5.002, p = 3.16 × 10

conclusionsThis study provided novel evidence that circulating GCKR levels are causally implicated in GDM and related complications, suggesting that it may be a promising target for treatment.

Indexed as

Adaptor Proteins, Signal TransducingDiabetes, GestationalCarrier ProteinsFemaleGenome-Wide Association StudyHumansMendelian Randomization AnalysisPolymorphism, Single NucleotidePregnancyAdaptor Proteins, Signal TransducingCarrier ProteinsGCKR protein, humanglucokinase regulatory proteingestational diabetes mellitusglucokinase regulatory proteinMendelian randomization

Identifiers

PMID39921581
PMCPMC11806411

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.