Evidence map›Paper›PMID 39921562›Full record

ArticleNucleic acids research2025

R2DT: a comprehensive platform for visualizing RNA secondary structure.

Holly McCann, Caeden D Meade, Loren Dean Williams, Anton S Petrov, Philip Z Johnson, Anne E Simon, David Hoksza, Eric P Nawrocki, Patricia P Chan, Todd M Lowe and 12 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  5. SnoRNA Expression and RNA 2'-O-Methylation inbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
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  11. Article
  12. Article
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  14. Article
  15. The Landscape of tRNA Modifications in Archaea.bioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Holly McCannNASA Center for Integration of the Origin of Life, Georgia Institute of Technology, Atlanta, GA 30332-0400, United States.ORCID 0000-0003-3308-0329
Caeden D MeadeNASA Center for Integration of the Origin of Life, Georgia Institute of Technology, Atlanta, GA 30332-0400, United States.ORCID 0000-0002-1800-5649
Loren Dean WilliamsNASA Center for Integration of the Origin of Life, Georgia Institute of Technology, Atlanta, GA 30332-0400, United States.ORCID 0000-0002-7215-4194
Anton S PetrovNASA Center for Integration of the Origin of Life, Georgia Institute of Technology, Atlanta, GA 30332-0400, United States.ORCID 0000-0003-3359-7299
Philip Z JohnsonDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, United States.ORCID 0000-0002-6689-8306
Anne E SimonDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, United States.ORCID 0000-0001-6121-0704
David HokszaDepartment of Software Engineering, Charles University, Prague 118 00, Czech Republic.ORCID 0000-0003-4679-0557
Eric P NawrockiNational Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, United States.ORCID 0000-0002-2497-3427
Patricia P ChanDepartment of Biomolecular Engineering, Baskin School of Engineering, University of California, Santa Cruz, CA 95064, United States.ORCID 0000-0003-0810-1642
Todd M LoweDepartment of Biomolecular Engineering, Baskin School of Engineering, University of California, Santa Cruz, CA 95064, United States.ORCID 0000-0003-3253-6021
Carlos Eduardo RibasEuropean Molecular Biology Laboratory, Wellcome Genome Campus, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, United Kingdom.ORCID 0000-0002-9572-273X
Blake A SweeneyEuropean Molecular Biology Laboratory, Wellcome Genome Campus, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, United Kingdom.ORCID 0000-0002-6497-2883
Fábio MadeiraEuropean Molecular Biology Laboratory, Wellcome Genome Campus, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, United Kingdom.ORCID 0000-0001-8728-9449
Stephen AnyangoEuropean Molecular Biology Laboratory, Wellcome Genome Campus, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, United Kingdom.ORCID 0000-0003-4838-443X
Sri Devan AppasamyEuropean Molecular Biology Laboratory, Wellcome Genome Campus, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, United Kingdom.ORCID 0000-0001-6609-3535
Mandar DeshpandeEuropean Molecular Biology Laboratory, Wellcome Genome Campus, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, United Kingdom.ORCID 0000-0002-9043-7665
Mihaly VaradiEuropean Molecular Biology Laboratory, Wellcome Genome Campus, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, United Kingdom.ORCID 0000-0002-3687-0839
Sameer VelankarEuropean Molecular Biology Laboratory, Wellcome Genome Campus, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, United Kingdom.ORCID 0000-0002-8439-5964
Craig L ZirbelDepartment of Mathematics and Statistics, Bowling Green State University, Bowling Green, OH 43403, United States.ORCID 0000-0002-3281-918X
Aleksei NaidenIndependent Researcher, Tbilisi, Georgia.ORCID 0009-0002-9210-1281
Fabrice JossinetFaculty of Life Sciences, University of Strasbourg, Strasbourg 67000, France.ORCID 0000-0003-4384-5735
Anton I PetrovRiboscope Ltd, 23 King Street, Cambridge CB1 1AH, United Kingdom.ORCID 0000-0001-7279-2682

Funding

A Unified Atlas of Dynamic tRNA FunctionR01HG006753 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI LOWE, TODD MICHAEL · 2012 to 2022
$4.6M
RNA 3D Motif Search, Atlas, and Prediction from SequenceR01GM085328 · NIGMS · BOWLING GREEN STATE UNIVERSITY · PI ZIRBEL, CRAIG L · 2010 to 2023
$4.0M
e-INFRA CZ projectEMBLMinistry of EducationNASA 80NSSC24K0344National Science Foundation 312990-00001National Science Foundation Graduate Research Fellowship Award DGE-1840340NHGRI NIH HHS R01 HG006753NIGMS NIH HHS R01 GM085328NIH HHS R01HG006753NLM NIH HHSNSF 2022065United States Department of Agriculture 308291-00001U.S. National Library of Medicine 20 894Wellcome Trust 223739WT 218302/Z/19/Z
6 · The paper itself

Abstract

RNA secondary (2D) structure visualization is an essential tool for understanding RNA function. R2DT is a software package designed to visualize RNA 2D structures in consistent, recognizable, and reproducible layouts. The latest release, R2DT 2.0, introduces multiple significant features, including the ability to display position-specific information, such as single nucleotide polymorphisms or SHAPE reactivities. It also offers a new template-free mode allowing visualization of RNAs without pre-existing templates, alongside a constrained folding mode and support for animated visualizations. Users can interactively modify R2DT diagrams, either manually or using natural language prompts, to generate new templates or create publication-quality images. Additionally, R2DT features faster performance, an expanded template library, and a growing collection of compatible tools and utilities. Already integrated into multiple biological databases, R2DT has evolved into a comprehensive platform for RNA 2D visualization, accessible at https://r2dt.bio.

Indexed as

Nucleic Acid ConformationRNASoftwareComputer GraphicsPolymorphism, Single NucleotideRNA FoldingRNA

Identifiers

PMID39921562
PMCPMC11806352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.