Evidence map›Paper›PMID 39921537›Full record

SynthesisInfluenza and other respiratory viruses2025

Trends in Proportions of Respiratory Syncytial Virus Infections Among Reported Respiratory Tract Infection Cases in Children Aged 0 to 5 Years in Western Pacific and Southeast Asia Regions: A Systematic Review and Meta-Analysis.

Sangshin Park, Hyelan Lee, Jung Yoon Park, Sujin Choi, Hyun Jung Kim, Lorenzo Bertizzolo, Young Hwa Lee, Young June Choe

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Influenza and other respiratory viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sangshin ParkGraduate School of Urban Public Health, University of Seoul, Seoul, South Korea.
Hyelan LeeGraduate School of Urban Public Health, University of Seoul, Seoul, South Korea.
Jung Yoon ParkGraduate School of Urban Public Health, University of Seoul, Seoul, South Korea.
Sujin ChoiMedical Affairs, Sanofi Pasteur, Seoul, South Korea.
Hyun Jung KimMedical Affairs, Sanofi Pasteur, Seoul, South Korea.
Lorenzo BertizzoloMedical Evidence Generation, Sanofi, Lyon, France.
Young Hwa LeeAllergy Immunology Center, Korea University, Seoul, South Korea.
Young June ChoeDepartment of Pediatrics, Korea University College of Medicine, Seoul, South Korea.ORCID 0000-0003-2733-0715

Funding

AstraZenecaSanofi Pasteur
6 · The paper itself

Abstract

backgroundRespiratory syncytial virus (RSV) is an important cause of bronchiolitis and pneumonia in children globally. This study aimed to incorporate new data to update estimates of RSV burden in children through 5 years of age in Western Pacific and Southeast Asia Regions.

methodsA systematic review and meta-analysis were conducted to examine the proportion of RSV among cases of respiratory tract infection (RTI) in children in Western Pacific and Southeast Asia Regions using random effects models. Studies were eligible if they met the following inclusion criteria: (1) observational studies such as cohort and cross-sectional studies; (2) studies on humans; (3) studies on patients with RTI or influenza-like illness (ILI); (4) studies reporting incidence or proportion of RSV infection among respiratory related illness; and (5) studies on children aged 5 years or less.

findingsA total of 4403 studies were identified from an initial search. After screening titles, abstracts, and full-text review, a total of 173 studies that met predefined eligibility criteria were included in the analysis. The overall proportion of RSV infections among all ARTIs was 18.7% (95% CI: 16.0%-21.5%), whereas the proportion of RSV infections among LRTIs was 28.7% (95% CI: 2.6%-30.3%) in children in Western Pacific and Southeast Asia Regions between 1970 and 2020. The proportion of RSV infections peaked in the 1980s at 33.4% (95% CI: 19.8%-48.5%), having increased from 10.6% (95% CI: 2.9%-22.2%) in the 1970s. It then showed a decreasing trend, with 28.9% (95% CI: 18.8%-40.3%) in the 1990s, 24.5% (95% CI: 22.3%-26.8%) in the 2000s, and 20.1% (95% CI: 17.8%-22.5%) in the 2010s. By country, Myanmar (50.0%; 95% CI, 47.5%-52.4%) and New Zealand (45.3%; 95% CI, 37.1%-53.7%) had the highest proportion during the overall time period, followed by Bhutan (45.2%; 95% CI, 36.4%-54.3%), Lao PDR (41.0%; 95% CI, 36.2%-46.0%), and Vietnam (35.5%; 95% CI, 19.3%-53.6%).

interpretationSubstantial RSV-associated disease burden occurs in children in Western Pacific and Southeast Asia Regions. Our findings provide new and important evidence of the need for RSV prevention in Western Pacific and Southeast Asia countries. They could inform future preventive policy.

Indexed as

Respiratory Syncytial Virus InfectionsRespiratory Tract InfectionsAsia, SoutheasternChild, PreschoolHumansIncidenceInfantInfant, NewbornPacific IslandsRespiratory Syncytial Virus, HumanAsiaburdenrespiratory syncytial virusRSV

Identifiers

PMID39921537
PMCPMC11806376

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.