NF2 is Essential for Human Endoderm Development.

Minjin Jeong, Dongjun Han, Preetida Bhetariya, D Bradley Welling, Miodrag Stojkovic, Konstantina M Stankovic

Abstract read

In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

NF2 is Essential for Human Endoderm Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Minjin JeongDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID https://orcid.org/0000-0002-1860-502X

Dongjun HanDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID https://orcid.org/0000-0002-8887-7039

Preetida BhetariyaBioinformatics Core, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.ORCID https://orcid.org/0000-0002-1988-3830

D Bradley WellingDepartment of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, 02114, USA.ORCID https://orcid.org/0000-0002-9963-469X

Miodrag StojkovicDepartment of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, 02114, USA.ORCID https://orcid.org/0000-0001-7526-6573

Konstantina M StankovicDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID https://orcid.org/0000-0003-0233-279X

Funding

Targeting HMGB1 to improve hearing andenhance therapy for Vestibular SchwannomasR01DC020724 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI Konstantina M Stankovic, Lei Xu · 2023 to 2026

$1.8M

Bertarelli Foundation ProfessorshipNIDCD NIH HHS R01 DC020724NIH HHS R01DC020724Remondi Foundation

6 · The paper itself

Abstract

Vertebrate embryogenesis requires the precisely timed specification of 3 germ cell layers- ectoderm, mesoderm, and endoderm- which give rise to tissues and organs in the developing organism. The tumor suppressor gene NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor (Nf2) is expressed in all 3 germ layers during mouse development and its homozygous deletion causes embryonic lethality. People with heterozygous NF2 mutations typically develop Schwann cell tumors, especially vestibular schwannoma, but the specific role of NF2 in human embryonic development is unclear. Here, human induced pluripotent stem cells (hiPSCs) are used to demonstrate that NF2 is essential for endoderm specification and formation in humans. Although endoderm differentiation is not impaired in hiPSCs with heterozygous NF2 mutation, NF2 knockout (NF2

Indexed as

EndodermNeurofibromatosis 2Neurofibromin 2YAP-Signaling ProteinsAnimalsCell DifferentiationCell LineDermisExonsFibroblastsGene Expression Regulation, DevelopmentalGene Knockout TechniquesHumansInduced Pluripotent Stem CellsMiceMutationNeurofibromin 2NF2 protein, humanYAP1 protein, humanYAP-Signaling Proteinsendodermhippo pathwayhuman induced pluripotent stem cellsNF2YAP1

Identifiers

PMID39921490

DOI10.1002/advs.202410909

PMCPMC12061267

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.