Evidence map›Paper›PMID 39921308›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Cortical Morphometric Similarity Remodeling in Traumatic Brain Injury Links Cognitive Impairments with Transcriptional Changes and Type-Specific Cells.

Yizhen Pan, Zhuonan Wang, Xiang Zhang, Wenpu Zhao, Haonan Zhang, Xuan Li, Xiaoyan Jia, Qiuyu Ji, Bo Yin, Guanghui Bai and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yizhen PanDepartment of Biomedical Engineering, School of Life Science and Technology, The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, China.
Zhuonan WangPET-CT Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Xiang ZhangDepartment of Biomedical Engineering, School of Life Science and Technology, The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, China.
Wenpu ZhaoDepartment of Biomedical Engineering, School of Life Science and Technology, The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, China.
Haonan ZhangDepartment of Biomedical Engineering, School of Life Science and Technology, The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, China.
Xuan LiDepartment of Biomedical Engineering, School of Life Science and Technology, The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, China.
Xiaoyan JiaDepartment of Biomedical Engineering, School of Life Science and Technology, The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, China.
Qiuyu JiDepartment of Biomedical Engineering, School of Life Science and Technology, The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, China.
Bo YinDepartment of Neurosurgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Guanghui BaiDepartment of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Tingting WuDepartment of Biomedical Engineering, School of Life Science and Technology, The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, China.
Zhiqi LeeDepartment of Biomedical Engineering, School of Life Science and Technology, The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, China.
Jierui DingDepartment of Biomedical Engineering, School of Life Science and Technology, The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, China.
Lei ShiDepartment of Biomedical Engineering, School of Life Science and Technology, The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, China.
Jie ZhangDepartment of Radiation Medicine, School of Preventive Medicine, Air Force Medical University, Xi'an, 710032, China.
David H SalatAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, 02114, USA.
Lijun BaiDepartment of Biomedical Engineering, School of Life Science and Technology, The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, China.ORCID https://orcid.org/0000-0002-9090-9335

Funding

National Key Research and Development Program of China 2023YFC3503600National Natural Science Foundation of China 82071993Natural Science Basic Research Program of Shaanxi Province 2022JC-55Natural Science Foundation of Shaanxi Province 2024SF-YBXM-387Shaanxi Province Postdoctoral Science Foundation (2024)
6 · The paper itself

Abstract

The heterogeneous injuries and resulting cognitive deficits pose significant challenges in the clinical management of mild traumatic brain injury (mTBI). However, the pathophysiological mechanisms related to heterogeneities of mTBI are still unclear. This study aims to explore the mechanisms underlying brain remodeling by examining the morphometric similarity (MS) alterations and corresponding transcriptomic signatures across adult and pediatric mTBI (adult mTBI: 112 acute patients, 47 follow-up chronic patients, 66 healthy controls [HCs]; pediatric mTBI: 30 acute patients, 31 HCs). A healthy adult cohort (N = 840) is included to derive the modularized brain MS networks representing interregional cortical connectivity. Subsequently, cortical MS remodeling patterns are identified involving mostly MS increases in the frontal modules with typical high MS and decreases in the occipital module with typical low MS, with more pronounced changes observed in the developing brain with mTBI. The abnormal MS changes are correlated with variable cognitive impairments. Moreover, cortical MS remodeling is also associated with the genes enriched in CA1 pyramidal cells and neuron-specific biological processes. The transcription-related cortical remodeling in mTBI might reveal the disruption of brain cellular architecture. Therapeutic modalities to intervene in specific cortex and tackle CA1 over-activation might better encircle the neurobiology of TBI.

Indexed as

Brain ConcussionBrain Injuries, TraumaticCerebral CortexCognitive DysfunctionAdolescentAdultChildFemaleHumansMaleMiddle AgedTranscriptomeYoung Adultcellscortical structural abnormalitymorphometric similarity networktranscriptiontraumatic brain injury

Identifiers

PMID39921308
PMCPMC11967866

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.