Evidence map›Paper›PMID 39921269›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Targeting the E Prostanoid Receptor EP4 Mitigates Cardiac Fibrosis Induced by β-Adrenergic Activation.

Hu Xu, Xiuhui Mao, Yali Wang, Chunhua Zhu, Bo Liang, Yihang Zhao, Mengfei Zhou, Lan Ye, Mengting Hong, Huishu Shao and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Comprehensive Plasma Oxylipin Profiling Reveals a Pro-Inflammatory Eicosanoid Signature and Diagnostic Biomarker Panel in Dilated Cardiomyopathy.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  3. Article
  4. Prostaglandin EEXCLI journal · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hu XuWuhu Hospital, East China Normal University, Shanghai, 200241, China.ORCID https://orcid.org/0000-0003-1198-0932
Xiuhui MaoHealth Science Center, East China Normal University, Shanghai, 200241, China.
Yali WangAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Chunhua ZhuHealth Science Center, East China Normal University, Shanghai, 200241, China.
Bo LiangAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Yihang ZhaoAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Mengfei ZhouAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Lan YeAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Mengting HongAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Huishu ShaoAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Yashuo WangAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Haonan LiMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, 116024, China.
Yinghui QiDepartment of Nephrology, Pudong New District Punan Hospital, Shanghai, 200125, China.
Yongliang YangMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, 116024, China.
Lihong ChenHealth Science Center, East China Normal University, Shanghai, 200241, China.
Youfei GuanHealth Science Center, East China Normal University, Shanghai, 200241, China.
Xiaoyan ZhangWuhu Hospital, East China Normal University, Shanghai, 200241, China.ORCID https://orcid.org/0000-0002-4060-2423

Funding

National Key R&D Program of China 2022YFA1104500National Natural Science Foundation of China 82270703National Natural Science Foundation of China 82370423Training program of key department of Pudong health system PWZzk2022-24
6 · The paper itself

Abstract

Sustained β-adrenergic activation induces cardiac fibrosis characterized by excessive deposition of extracellular matrix (ECM). Prostaglandin E

Indexed as

FibrosisReceptors, Adrenergic, betaReceptors, Prostaglandin E, EP4 SubtypeAdrenergic beta-AgonistsAnimalsFibroblastsIsoproterenolMaleMiceMice, KnockoutMyocardiumMyocytes, CardiacAdrenergic beta-AgonistsIsoproterenolPtger4 protein, mouseReceptors, Adrenergic, betaReceptors, Prostaglandin E, EP4 Subtypecardiac fibroblastcardiac fibrosiscardiomyocyteEP4 receptorisoproterenolTGF‐β signaling

Identifiers

PMID39921269
PMCPMC11948031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.