ArticleMedical science monitor : international medical journal of experimental and clinical research2025
Immune Dysregulation in Acute Herpes Zoster: Predictive Factors for Postherpetic Neuralgia.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Construction and validation of a prediction system for postherpetic neuralgia: based on meta-analysis.Scientific reports · 2026Pooled it
- Herpetic reactivation during radiotherapy treatment for gynaecological cancers-a retrospective observational study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- Nomogram-Based Prediction Model for Postherpetic Neuralgia in Immunosuppressive Patients.Journal of clinical medicine · 2026Article
- A pilot imaging mass cytometry study of cutaneous nerve-immune cell interactions in post-herpetic neuralgia.Frontiers in immunology · 2026Article
- Construction of influencing factors and nomogram prediction model for post-herpetic neuralgia based on T cell function and inflammatory factors.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Postherpetic neuralgia (PHN) is closely related to the host immune response. This study explored the cellular and humoral immune functions of acute immunocompetent herpes zoster (HZ) patients and their relationship with PHN. MATERIAL AND METHODS We selected 188 patients with acute HZ admitted to our hospital and 79 individuals who underwent physical examinations during the same period. We measured and compared the levels of peripheral blood lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+, CD19+, CD56+), serum immunoglobulins (IgA, IgG, IgM), and complement (C3, C4) between the 2 groups. Based on whether they had neuralgia during follow-up, we divided the patients into an HZ-PHN group and an HZ-control group, and compared their differences in immune functions and their relationship with PHN. RESULTS Compared with the control group, the levels of CD3+ and CD4+ and CD4+/CD8+ ratios of HZ patients were significantly lower (P<0.05). Among 188 HZ patients, 91 (48.4%) developed PHN. The patients in the HZ-PHN group were significantly older (P<0.01) and the levels of CD3+, CD4+, and CD8+ and CD4+/CD8+ ratios were significantly lower than those in the HZ-control group (P<0.05, P<0.01). Binary logistic regression analysis showed that age and CD4+/CD8+ ratios are independent risk factors for determining whether HZ patients develop PHN. CONCLUSIONS Acute immunocompetent HZ patients, especially those who are older and more prone to developing PHN, exhibit significant cellular immune dysregulation. Age and CD4+/CD8+ ratios may be useful predictors of PHN in acute HZ patients.
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