Evidence map›Paper›PMID 39921108›Full record

ArticleJournal of the American Academy of Dermatology2025

An international multicenter, retrospective cohort study of 203 patients with pediatric androgenetic alopecia.

Tyan Shin Lee, Mara O'Connor, Leslie Castelo-Soccio, Dawn Eichenfield, Danny Lee, Amy S Paller, Manuel Valdebran, Jenna Vroman, Angela Yang, Grace L Lee and 2 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of the American Academy of Dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tyan Shin LeeDivision of Dermatology, The Hospital for Sick Children, Toronto, Canada.
Mara O'ConnorDepartments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Leslie Castelo-SoccioNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.
Dawn EichenfieldDepartment of Dermatology, University of California San Diego, San Diego, California.
Danny LeeDepartment of Dermatology, University of California San Diego, San Diego, California.
Amy S PallerDepartments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Manuel ValdebranDepartment of Dermatology, Medical University of South Carolina, Charleston, South Carolina.
Jenna VromanDepartment of Dermatology, Medical University of South Carolina, Charleston, South Carolina.
Angela YangDepartments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Grace L LeeDivision of Dermatology, Texas Children's Hospital, Houston, Texas.
Megan CraddockDivision of Dermatology, Kelsey-Seybold Clinic, Houston, Texas.
Cathryn SibbaldDivision of Dermatology, The Hospital for Sick Children, Toronto, Canada. Electronic address: cathryn.sibbald@sickkids.ca.

Funding

Intramural NIH HHS Z99 AR999999
6 · The paper itself

Abstract

backgroundAndrogenetic alopecia (AGA) is a nonscarring alopecia with increasing prevalence in pediatric populations. Published data in pediatrics are limited.

objectiveTo perform a multicenter review of pediatric patients with AGA to study clinical presentation, comorbidities, and treatment recommendations.

methodsA retrospective review of patients presenting with AGA at age <18 years with adequate documentation for data extraction.

resultsIn total, 203 patients were included. The mean age of AGA onset was 12.9 ± 2.7 years, and at diagnosis was 14.5 ± 2.1 years. Prepubertal onset occurred in 17 patients, 70.6% female. The majority had a family history of AGA. Of 145 patients with anthropometric data, 24.1% were obese (>95th percentile) and 24.8% overweight (85-95th percentile). Treatments at diagnosis included topical minoxidil in 76.5% and systemic minoxidil in 2.9%, spironolactone in 5.7% of females, and 5-alpha reductase inhibitors in 1.7% of males. Side effects were rare. LIMITATIONS: Data were limited to recorded information.

conclusionAGA can occur in prepubertal patients. Potential risk factors for pediatric AGA include obesity and family history. Minoxidil has clinical benefit and is well tolerated in this population. Further prospective studies are recommended to confirm these findings and gather more evidence for treatments.

Indexed as

Alopecia5-alpha Reductase InhibitorsAdolescentAge of OnsetChildChild, PreschoolCohort StudiesFemaleHumansMaleMinoxidilRetrospective StudiesRisk FactorsSpironolactone5-alpha Reductase InhibitorsMinoxidilSpironolactoneandrogenetic alopeciapediatrics

Identifiers

PMID39921108
PMCPMC12101953

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.