Evidence map›Paper›PMID 39921034›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2025

Crystallization of supersaturated PEG-b-PLA for the production of drug-loaded polymeric micelles.

Morteza Rasoulianboroujeni, Rae Hyung Kang, Maraya Klukas, Glen S Kwon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Morteza RasoulianboroujeniPharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705, United States.
Rae Hyung KangPharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705, United States; Department of Pharmaceutical Engineering, Dankook University, Cheonan 31116, Republic of Korea.
Maraya KlukasPharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705, United States.
Glen S KwonPharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705, United States. Electronic address: glen.kwon@wisc.edu.

Funding

Oligo(lactic acid)n-Prodrug Nanomedicines for Combination TherapyR01CA257837 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KWON, GLEN S. · 2021 to 2024
$1.4M
NCI NIH HHS R01 CA257837
6 · The paper itself

Abstract

In this study, we propose the "crystallization from supersaturated solution" method for producing drug-loaded polymeric micelles. This method involves the formation of solid drug-encapsulating crystals of a diblock copolymer through isothermal crystallization from a supersaturated solution of the copolymer in low molecular weight PEGs containing the drug, followed by dissolution of the crystals to obtain drug-loaded micelles. We fabricated and characterized micelles loaded with several model drugs (paclitaxel, rapamycin, and docetaxel) and their oligo(lactic acid)

Indexed as

Antineoplastic AgentsDrug CarriersMicellesPolyethylene GlycolsProdrugsCell Line, TumorCell SurvivalCrystallizationDocetaxelDrug LiberationHumansPaclitaxelParticle SizeSirolimusAntineoplastic AgentsDocetaxelDrug CarriersMicellesPaclitaxelPolyethylene GlycolsProdrugsSirolimusDrug-loaded polymeric micelles productionIsothermal crystallizationPolyethylene glycol-block-polylactic acid (PEG-b-PLA)Prolonged storageSolid form

Identifiers

PMID39921034
PMCPMC11908913

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.