Evidence map›Paper›PMID 39920875›Full record

ArticleEuropean journal of medical research2025

Biochemical analysis of miR-217 and miR-532 in patients with fibromyalgia.

Shymaa E Ayoub, Azza M Ahmed, Mostafa Y Abdelwahed, Abeer A Khalefa, Aeshah A Awaji, Samer S Zekry, Enas G Ibrahim, Hana M Eid, Shimaa M Elasmer, Reham Fares

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In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shymaa E AyoubMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt. ssa05@fayoum.edu.eg.ORCID http://orcid.org/0000-0003-1688-3891
Azza M AhmedRheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Mostafa Y AbdelwahedDepartment of Physiology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Abeer A KhalefaDepartment of Physiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Aeshah A AwajiDepartment of Biology, Faculty of Science, University College of Taymaa, University of Tabuk, 71491, Tabuk, Saudi Arabia.
Samer S ZekryDepartment of Internal Medicine, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Enas G IbrahimDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Hana M EidDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Shimaa M ElasmerDepartment of Clinical and Chemical Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Reham FaresMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

About 5% of the population suffers from fibromyalgia (FM), a chronic multi-symptom pain illness whose pathophysiology is still unknown. We aimed to be the first to investigate the possible association of sera levels of miR-217 and miR-532 in patients with fibromyalgia and correlate their expression levels to different clinical and biochemical disease criteria. This study included 80 participants who splitted into two groups: 40 fibromyalgia sufferers (12 male and 28 female), and 40 healthy volunteers (10 male and 30 female) who served as the control group. Venous blood samples were collected from all subjects. The miR-217 and miR-532 serum expressions were detected using quantitative real-time PCR (qRT-PCR). According to our data, the fold changes of miR-217 and miR-532 in fibromyalgia patients were significantly lower than in controls, for miR-217 (median = 0.1359, IQR: 0.038-0.287, P < 0.001) and miR-532 [median = 0.2199, IQR: (0.114-0.421), P < 0.001]. In addition, there was a significant negative relationship between Aspartate transaminase (AST) and both miR-217 and miR-532 (r = - 0.480, P = P < 0.001 r = - 0.462, P = P < 0.001), respectively. Serum miR-217 and miR-532 could serve as potential diagnostic biomarkers for fibromyalgia.

Indexed as

FibromyalgiaMicroRNAsAdultBiomarkersCase-Control StudiesFemaleHumansMaleMiddle AgedBiomarkersMicroRNAsMIRN217 microRNA, humanMIRN532 microRNA, humanFibromyalgiaMiR-217MiR-532

Identifiers

PMID39920875
PMCPMC11803959

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.